Question

Please provide thee full pathologic explanation and references why the pulse rate is 138/min in septic shock?

Answer 1

The underlying mechanism of such persistent arrhythmia may be associate altered chronotropic response, thanks to associate impairment of the sympathetic system (SNS) and, especially, of SNS mediate organs interactions. In fact, it's currently well understood that some septic shock patients might suffer from a extended and overshooting stimulation of the SNS, which can exceed in time and scope the useful short offsetting impact, resulting in many adverse effects, like prolonged arrhythmia.
Moreover, beside the physiological endogenous unleash of chatecholamines, the high doses of exogenous chatecholamines thanks to aggressive medical aid with dobutamine or monoamine neurotransmitter, any increase unit of time and therefore the risk of viscus failure . For these reasons, in septic . At present, most of research project into viscus impairment in septic shock and multiorgan pathology syndrome (MODS) focuses on heart muscle depression thanks to microorganism toxins and inflammatory mediators.

ANS plays a key role to revive the lost physiological state, and, once its practicality isn't with success recovered, the revival isn't effective, as already rumored in different recent researches of our cluster . Moreover, this work is in line with previous studies that determined a persistently elevated viscus frequency and ability when revival in septic patients, associated explained this development with an impairment of the ANS.