Gram Negative Bacilli, choose one pathogen from the list and answer the following: DO NOT USE...

Gram Negative Bacilli, choose one pathogen from the list and answer the following: DO NOT USE Corynebacterium diptheriae causes diptheria Describe one disease process of the pathogen (how does it infect the person, what does it do on a cellular and tissue level to cause signs and symptoms). What are the signs and symptoms? What is the general treatment plan? Your main post should be the first post to avoid penalties. Come back at least twice to respond with educational and quality responses based on research. please do not copy and paste answers from google. do not upload a handwritten cursive response. type the text only.

Expert Solution

Ans. Corynebacterium diptheria manifests in the upper respiratory tract. Those who are not completely immunized are the ones susceptible for the infection, the cases where the individual have been exposed to disease and in whom the antitoxin antibody level are pretty much low. Exotoxins of the so called bacterium are concerned with the invasive localized and systematic forms of disease. Exotoxins are encoded in bacteriophages and transferred from bacteria to bacteria.

The transmission of bacteria occurs by respiratory droplets and nasopharyngal secretions. C diptheria adheres to mucosal epithelial cells and thus release exotoxin by endosomes which causes tissue destruction and necrosis. Toxin is a combination of two protein, B segment adheres to host cell causing protolytic cleavage. IT allows the segment A to enter. The A fragment inhibits amino acid transfer from RNA translocase to ribosomal amino acid chain, which inhibits protein synthesis. It inactivates the elongation factor, resulting in protein synthesis inhibition and subsequently cell death.

Tissue destruction results in the tranfer of toxin to other parts of the body and vital organs.

Signs and symptoms are:

1) Fever

2) Difficulty in swallowing

3) hoarsness

4) enlarged lymph nodes

5) coughing and shortness in breath

Treatment:

Comprises of use of antitoxins derived from horse the treatment due to exotoxin.

gladiator answered 2 years ago

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