Question

Which of the following consequences of a signaling molecule binding to its receptor is NOT a short-term response?

	chromatin remodeling, resulting in transcriptional changes
	ubiquitination of a target protein, resulting in its degradation
	phosphorylation by a kinase
	cAMP binding and protein activation

Answer 1

Answer: Option 1: Chromatin remodeling, resulting in transcriptional changes

In chromatin remodelling, chromatin remodelers helps in modifying the chromatin that allows the transcriptional signals to reach their destinations on the DNA. This takes a long time and is not a short term response

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Option 2 ubiquitination of a target protein, resulting in its degradation: Addition of mutliple copies of ubiquitin helps in targeting a protein for destruction by forming an intracellular protease known as 26s proteasome. This is a short term response

Option 3 Phosphorylation by a kinase: Protein kinase modifies proteins by addition of phosphate groups through process of phosphorylation which is a rapid and short term response

Option 4 cAMP binding and protein activation: Protein kinase A depends of cAMP (cyclic AMP) which is responsible for many short term responses involved in regulation of glycogen, sugar and lipid metabolism

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Hence, the correct answer is option 1 chromatin remodeling, resulting in transriptional changes