Question

i. Type II hypersensitivity or antitotoxic reaction of the antibody involves the following EXCEPT

A. is mediated by antibodies such as IgG and IgM.

B. is a toxicotoxicity mediated by complement

C. Causes antibody-mediated body cell dysfunction

D. The body's cytotoxicity is mediated by cells such as antibody-dependent macrophages

E. The production of too many antibodies against the bacterial cells that make up the immune complex.

ii. The function of eosinophils in Type I hypersensitivity is
A. neutralizes vasoactive factors from cell poles.
B. avoid insects start biting.
C. polar cell degeneration cells.
D. The release of prostaglandins.
E. destroy the larval worm.

Answer 1

Answer 1--A --wrong

type 1 hypersensitivity reaction also called as anaphylatic reaction it is antibody mediated reaction

example --bronchial asthma ,good and pollen allergy allergic rhinitis etc

Pathogenesis-- when antigen enter in body it is revognised by antigen presenting cells

And antigen presenting cell digest it and represent on their surface it is stimulate T helper 2

T helper release interleukin 4 which stimulate release of IgE antibody

and also release interleukin 5 which recruitment of eosinophils

On first expisure mast cell sensitize for the antigen

further exposure..polymerisation and degranulation of mast cell

Occur early phase reaction--due to preformed mediators
, histamin which cause vasodilation and brochial muscle contraction

On late phase reaction--cytokine leukokine chemokine release and causes tissue distruction and epithelial damage

Answer 2-- eosinophil stimulate to release of prostaglandin histamin chemokine leukotriens