Question

What would each of the following be predicted to achieve regarding cancer development?Explain you answer.

A patient takes low dose aspiring for many years.

An individual inherits a defective version of the XPA gene, a component of the nucleotide excision repair pathway, from each of his parents.

A low grade tumor cell hypermethylates the promoter for Mad2, a component of the spindle assembly checkpoint.

A patient with a rapidly growing tumor receives an experimental treatment consisting of a potentangiogenesis inhibitor.

Answer 1

• Answer - a,b,c and d
• Aspirin is a antiinflammatory drug that can be used to decrease the chance of cancer by fighting with chronic type of inflammation, which can later become cancerous.
• It prevents cancer by preventing the increase in number of cells by decreaing the inflammatory actions. Hence option a is correct.
• XP is a normal gene present in individuals. XPA is its mutant type. Presence of XPA can cause the chance of skin cancer in patients. The progenies can get this mutant type by inheriting it from their parents. Hence b is correct.
• Hypermethylation can cause decrease in the transition of cell from metaphase to anaphase, by inhibiting Mad2. Thus decreasing the tumour cell progression. Thus this method can be used to prevent cancer. So c is correct.
• Tumour cells can be controlled by limiting the about of nutrients availabe to them, thus leading them to starvation. it can be achieved by using potent angiogenesis inhibitor, thus controlling blood supply by directluy controlling the nutrient supply to the cell. hence d is correct.