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SARS emerged in 2003, spread to 26 countries with more than 8000 cases (WHO) with a...

  1. SARS emerged in 2003, spread to 26 countries with more than 8000 cases (WHO) with a case fatality rate (CFR – the death rate) of 11%. MERS emerged in 2012 and had a CFR of 35%. It is very difficult to estimate the CFR of COVID-19 worldwide, and CFRs will differ in different countries (due to health systems, and underlying population demographics), but ranges seem to be between 0.5% and 3%. Why is SARS-CoV-2 more dangerous than SARS-CoV-1 or MERS given it has a lower death rate? (~300 words, include a short reference list)

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Expert Solution

The SARS COV-2 viruses are group of viruses that have been seem to be originated in the Chinese Meat market of Wuhan from bats or pangolians and had jumped on human host and they have evolved in humans much more efficiently.They belong to same family of SARS COV1 viruses and even though they have less death rate but currently they have created a worldwide pandemic in the world infecting millions of people mainly dangerous in small children and adult.The various reasons for COV2 aggressiveness is though its receptors are similar as of SARS COV-1 but they can stick much more easily and spread through the sysem fast.The virus attacks bronchial tubes and lungs causing sever pneumonia.Also due to spread of virus the immune system reacts and leads to a cytokine storm which can though helps in geting rid from virus but if this sticks from a long time this cytokine response can cause lungs damage,kidney clots and even heart aatack,H resulting in severe indirect attacks due to the virus.Also due to unique receptors the no new direct drug and vaccinations are developed against this virus and so the spread is much more rapid.

Source-UCI Health blog

The Deadly Coronaviruses: The 2003 SARS Pandemic and the 2020 Novel Coronavirus Epidemic in China. NCBI article.


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