Question

Describe the relationship between the endocrine system and a healthy bone turnover.

Answer 1

Ans) Relationship between the endocrine system and a healthy bone turnover:

- Bone has been viewed as a relatively static tissue function of which are for locomotion, body support, and organ protection, regulation of numerous metabolic processes that are independent of mineral metabolism.

- Bone integrity and its normal function depend on other organs but may also affect them.

- Emerging evidence suggests that bone is metabolically active and can be considered as a true endocrine organ, thus its relationship revealing an integrative physiology where bone takes an important role in regulating intermediary metabolism.

- Indeed, bone has been considered an endocrine organ because of its capacity to secrete osteocalcin, a molecule expressed by the most osteoblast-specific gene.

- Epidemiological studies in humans performed to analyze the relationship between osteocalcin and metabolic parameters, such as glycaemia, insulin secretion, ?-cell proliferation, and lipid profile, have added information on the potential impact of the skeleton on energy regulation and glucose metabolism, through osteocalcin.