Question

            Chromosome Chromosome

            Locus Number Locus   Number                     

TPOX		2			TH01		11
D3S1358		3			VWA		12
FGA		4			D13S317		13
D5S818		5			D16S539		16
CSF1PO		5			D18S51		18
D7S820		7			D21S11		21
D8S1179		8

Table 1.

Locus	Alleles	Frequency	Locus RMP
TPOX	8 12	0.535 0.041
TH01	10 10	0.008
D3S1358	16 17	0.222 0.222
FGA	21 23	0.0185 0.134
CSF1PO	11 13	0.301 0.096
D8S51	14 19	0.137 0.038
D21S11	28 29	0.159 0.195

1. If you haven’t already done so, calculate the RMP for each of Jane’s loci using the provided allelic frequency information in Table 1 above.  Please show your work.

2. What are the chances of two people sharing Jane’s TPOX and TH01 alleles?  Please show your work. (You may use exponents and round off your answer to two decimal places, eg: 1.21 x 10^-7)

3. What are the chances of someone sharing Jane’s TPOX and TH01 and FGA alleles?  Please show your work. (You may use exponents and round off your answer to two decimal places, eg: 1.21 x 10^-7)

4. Now calculate the total RMP (random match probability) that Jane’s DNA profile above matches the crime scene DNA purely by coincidence? Please show your work. (You may round off your answer to two decimal places and use exponents, eg: 1.21 x 10^-7)

Answer 1

Answer a:)

To calculate RMP of each genotype, multiply all allele frequencies of the genotype.

Therefore,

RMP of TPOX locus = 0.535 x 0.041

RMP of TPOX locus = 0.022

RMP of TH01 locus = 0.008

RMP of D3S1358 locus = 0.222 x 0.222

RMP of D3S1358 locus = 0.049

RMP of FGA locus = 0.0185 x 0.134

RMP of FGA locus = 0.002

RMP of CSF1PO locus = 0.301 x 0.096

RMP of CSF1PO locus = 0.029

RMP of D8S51 locus = 0.137 x 0.038

RMP of D8S51 locus = 0.005

RMP of D21S11 locus = 0.159 x 0.195

RMP of D21S11 locus = 0.031

Answer b:)

If people share Jane’s TPOX and TH01 alleles, possible chances = RMP of TPOX x RMP of TH01

If people share Jane’s TPOX and TH01 alleles, possible chances = 0.022 x 0.008

If people share Jane’s TPOX and TH01 alleles, possible chances = 0.000176

If people share Jane’s TPOX and TH01 alleles, possible chances = 1.76 x 10-4

Answer c:)

If people share Jane’s TPOX, FGA and TH01 alleles, possible chances = RMP of TPOX x RMP of TH01 x RMP of TH01

If people share Jane’s TPOX, FGA and TH01 alleles, possible chances = 0.022 x 0.008 x 0.002

If people share Jane’s TPOX, FGA and TH01 alleles, possible chances = 0.000000352

If people share Jane’s TPOX, FGA and TH01 alleles, possible chances = 3.52 x 10-7

Answer d:)

Total RMP is the multiplication of all allele frequencies. Therefore, total RMP = 0.022 x 0.049 x 0.002 x 0.029 x 0.005 x 0.031

Total RMP is the multiplication of all allele frequencies. Therefore, total RMP = 9.69 x 10-12