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Sludy Guicde Questions: 1. Construct a lable comparing/citing the diflerences between oncogenes and TSG
Sludy Guicde Questions:
1. Construct a lable comparing/citing the diflerences between
oncogenes and TSG
Solutions
Expert Solution
| Comparison | Oncogenes | Tumour suppressor genes (TSGs) | Citations |
| 1. | These are formed from Protooncogenes, responsible for causing cancer. | These are inactivated, resulting in the Cancer. | Lodish H, Berk A, Zipursky SL, et al. Molecular Cell Biology. 4th edition. New York: W. H. Freeman; 2000. Section 24.2, Proto-Oncogenes and Tumor-Suppressor genes. https://www.ncbi.nlm.nih.gov/books/NBK21662/ |
| 2. | Mutation in either one of the allele is sufficient to cause the phenotype. | Both alleles must be mutated to cause the phenotype | Zhu K, Liu Q, Zhou Y, et al. Oncogenes and tumor suppressor genes: comparative genomics and network perspectives. BMC Genomics. 2015;16 Suppl 7(Suppl 7):S8. doi:10.1186/1471-2164-16-S7-S8 |
|
3. |
In these the mutation occurs in the somatic cells and it is not inherited. | In this mutation is present both in somatic and germ cells (can be inherited) | |
| 4. | Gain of function of a protein that signals cell proliferation and division. | Loss of function of a protein, that regulates unwanted cell proliferation. | Wrzeszczynski KO, Varadan V, Byrnes J, et al. Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer. PLoS One. 2011;6(12):e28503. doi:10.1371/journal.pone.0028503 |
| 5. | Some tissue preference is present. |
These exhibit stronger tissue preference. eg- effect of RB gene on the retina. |
Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature. 1991;351(6326):453-456. doi:10.1038/351453a0 |
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