A patient with multiple carboxylase deficiency will benefit from a dietary restriction of these amino acids...

A patient with multiple carboxylase deficiency will benefit from a dietary restriction of these amino acids except _____ ? Methionine Isoleucine Threonine Serinem

Expert Solution

ANSWER :-

First of all, the enzyme biotinidase is responsible for biotin synthesis in body. In case of formation of biotin, biocytin is an important precursor substrate for the enzyme biotinidase. Basically, there is association of the biotin molecule with amino acids like lysine which is bound to biotin forming biocytin and then cleaved in the presence of enzyme biotinidase.
Although, it should be taken into consideration that out of the four amino acids mentioned above, three are essential amino acids including Methionine, Isoleucine and Threonine. Serine is non-essential amino acid.
Avidin is a protein which binds to the biotin and has inhibitory role in terms of altering biotin function with respect to the functioning of the carboxylatoon system which utilised biotin. This condition could result in Multiple carboxylase deficiency affecting the primary carboxylases such as pyruvate carboxylases, Acetyl-CoA carboxylase, methylcrotonyl coA carboxylase, etc.
Avidin is found in egg white and does not contain amino acid Serine but has all essential amino acids and egg should not be consumed by a person having the condition. So, according to me option 'D' which is Serine is the most appropriate answer as Its supplementation is not avoided. But, this can vary depending upon the type of answer one is expecting.

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gladiator answered 6 months ago

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