Question

This is a Biochemistry Question!

Please select all of the following processes that would INCREASE during untreated or badly managed diabetic ketoacidosis: (More than 1 answer)

1) there is fluid and electrolyte loss in urine

2) plasma pH

3) Glucose uptake & skeletal muscle using as primary fuel

4) Bicarbonate reabsorption & renal Hydrogen excretion

5) Relying on fatty acids & proteins as primary fuels throughout the body

6) Gluconeogenesis, Fatty acid oxidation, & ketogenesis (all within the liver)

7) Lipolysis & fatty acid release from adipose

Answer 1

Answer-

According to the given question-

diabetic ketoacidosis- is a complication considered of type 1 diabetes and this condition is due to high amount of acidic substances or ketones, and blood sugar present inside the body.Because our body cannot able to produce insulin and due to which fat is used as primary fuel that are responsible for producing ketones.

When there is no insulin then glucose is not utilized by body so liver produces more glucose required for body need and this causes increase of blood sugar . Then fat is broken down for require of energy by body into ketones and this ketones accumulated in bloodstream. when it reaches to kidney then kidney uses water to clear the glucose and ketone due to which high amount of water is lost and lead to dehydration and ketoacidosis. both glucose and ketones are transferred into urine.

1) there is fluid and electrolyte loss in urine - true - because of hyperglycemia along with that there is glycosuria and osmotic diuresis.

2) plasma pH- true- also increases due to hyperglycemia

3) Glucose uptake & skeletal muscle using as primary fuel - false- in glucose uptake decreases and lipolysis increases.

4) Bicarbonate reabsorption & renal Hydrogen excretion- false - it decreases

5) Relying on fatty acids & proteins as primary fuels throughout the body- True - because glucose cannot be utilized due to lack of insulin.

6) Gluconeogenesis, Fatty acid oxidation, & ketogenesis (all within the liver)- true it increases , Glycogenolysis as well as Gluconeogenesis increases in liver.

7) Lipolysis & fatty acid release from adipose - glucose uptake decreases and lipolysis increases.

So the correct options are 1, 2, 5. 6. 7.