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In: Anatomy and Physiology

Describe the interplay between: the juxtaglomerular apparatus, the renin-angiostensin pathway, aldosterone, and the distal convulated tubules...

Describe the interplay between: the juxtaglomerular apparatus, the renin-angiostensin pathway, aldosterone, and the distal convulated tubules of the kidney

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Expert Solution

Answer : The interplay between: the juxtaglomerular apparatus, the renin-angiostensin pathway, aldosterone, and the distal convulated tubules of the kidney is related to each other

-The renin-angiotensin system (RAS) / The renin-angiotensin-aldosterone system (RAAS) is a hormone system that regulates blood pressure  and water (fluid) balance.
When blood volume is low, juxtaglomerular cells in the kidneys secrete renin ( Hormone ) directly into circulation. Plasma renin then carries out the conversion of angiotensinogen released by the liver to angiotensin I. Angiotensin I is subsequently converted to angiotensin II by the enzyme angiotensin converting enzyme found in the lungs. Angiotensin II is a potent vaso-active peptide that causes blood vessels to constrict, resulting in increased blood pressure( vasoconstriction). Angiotensin II also stimulates the secretion of the hormone aldosterone from the adrenal cortex. Aldosterone causes the distal convoluted tubules of the kidneys to increase the reabsorption of sodium and water into the blood result in increase osmotic pressure.This increases the volume of fluid in the body, which also increases blood pressure... Thanks dear student


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