In: Biology
1. A biochemistry student was culturing a population of bacteria at less than 20 degrees Celsius. After some hours, the temperature was raised to 37 degrees Celsius. What would be the consequent effect of this change in the
(a) fatty acid composition of the membrane?
(b) transition temperature of the lipid bilayer?
2. Cardiac glycosides are natural products that increase the intensity of heart muscle contraction. Among them are (a) digitalin – from digitalis, an extract of purple foxglove leaves and has been used to treat congestive heart failure for centuries and; (b) ouabain (pronounced wabane) – a product of the East African ouabio tree and has been long used as an arrow poison.
(a) What are the structures of these cardiac drugs?
(b) How do they affect the (Na+-K+)-ATPase? The cellular Na+ concentration? Explain the mechanisms
(c) activity of the enzymes, membrane desaturases?