What percentage of carbon atoms in cholesterol are derived from acetyl-coA?

Expert Solution

The synthesis of cholesterol takes place mainly in liver. Cholesterol is key component of cell membranes. It is also precursor of many steroid hormones.

Cholesterol contains 27 carbons. 4 rings along with a side chain is present in cholesterol.

All the 27 carbons of cholesterol are derivatives of acetyl CoA. Hence, 100% carbon atoms of cholesterol are derived from acetyl coA.

The synthesis of cholesterol starts from condensation of two acetyl co A to form Acetoacetyl co A. Then one more acetyl CoA is added to form mevalonate.by enzyme HMG co A reductase. It is rate limiting step in cholesterol synthesis.

Then isoprene units are formed by mevalonate by sequential phosphorylation and decarboxylation.

Afterwards, 6 isoprene units are condensed to form squalene. Later on cyclization of squalene happens to form lanosterol and cholesterol is formed ultimately.

Therefore, all the carbon atoms are contributed by acetyl coA only.

gladiator answered 2 years ago

169. What percentage of carbon atoms in cholesterol are derived from acetyl-coA? 171. For every starting...

169. What percentage of carbon atoms in cholesterol are derived from acetyl-coA? 171. For every starting molecule of glucose, how many NTPs are made directly in the Citric Acid Cycle (not including any ATP made in the ETC)? 174. Under actual cellular conditions, how many strongly exergonic reactions take place in glycolysis? 168. How many fatty acid chains are attached to a membrane phospholipid? ANSWER ALL THE QUESTION PLEASE

COA The acetate of acetyl COA undergoes a stepwise oxidation to carbon dioxide and water in...

COA The acetate of acetyl COA undergoes a stepwise oxidation to carbon dioxide and water in a cyclic pathway Explain in detail the ca (

During acetyl CoA formation and the citric acid cycle, all of the carbon atoms that enter cellular respiration in the glucose molecule are released in the form of CO2.

Part A - Carbon atoms in acetyl CoA formation and the citric acid cycle During acetyl CoA formation and the citric acid cycle, all of the carbon atoms that enter cellular respiration in the glucose molecule are released in the form of CO2. Use this diagram to track the carbon-containing compounds that play a role in these two stages. Drag the labels from the left (which represent numbers of carbon atoms) onto the diagram to identify the number of carbon...

What is the term for conversion of acetyl CoA into energy in the form of ATP...

What is the term for conversion of acetyl CoA into energy in the form of ATP in the presence of oxygen? a. oxidative phosphorylation b. citric acid cycle c. proton gradient d. cellular respiration e. electron-transport chain

A 12 carbon fatty acid generates 6 molecules of acetyl CoA. How many molecules of ATP...

A 12 carbon fatty acid generates 6 molecules of acetyl CoA. How many molecules of ATP can be generated from this fatty acid if you consider the production all the way through the electron transport chain?

What conditions are required to obtain energy from acetyl CoA in the citric acid cycle? Select...

What conditions are required to obtain energy from acetyl CoA in the citric acid cycle? Select all that apply. a. availability of O2 b. availability of CO2 c. anaerobic conditions d. low energy charge e. high energy charge

Explain the regulation of the allosteric enzyme acetyl-CoA carboxylase by citrate and palmitoyl-CoA.

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during...

In glycolysis, the conversion from pyruvate to acetyl CoA is irreversible, but I found that during the synthesis of FA, acetyl CoA can be synthesized to citrate -> OAA -> Malate ->pyruvate when Citric acid shuttle, why we cannot say that pyruvate can turn back to acetyl CoA?

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from...

11. In the Pyruvate Dehydrogenase complex, the acetyl unit is passed to the coA directly from __________________. A. biotin B. TPP C. FAD D. pyruvate E. lipoyllysine 13. A common feature of molecules that signal through steroid and metabolite hormone receptors is: A. they are hydrophobic B. they are polar C. their receptors are mostly found in the cell surface membrane D. their receptors signal through second messengers. E. their...

How many molecules of acetyl-CoA, FADH2 and NADH, and their corresponding electrons are produced from the...

How many molecules of acetyl-CoA, FADH2 and NADH, and their corresponding electrons are produced from the beta-oxidation of docosanoic acid? From the acetyl CoA produced, how many molecules of FADH2 and NADH are produced? Overall, approximately how many molecules of ATP will docosanoic acid ultimately produce?

Question