Question

The metabolism of ethanol by alcohol dehydrogenase produces reduced nicotinamide adenine dinucleotide (NADH). What effect is the change in the NAD+/NADH ratio expected to have on gluconeogenesis? Explain in full details

Answer 1

◆ metabolism of ethanlol by alcohol dehydrogenase :-

• refer TABLE 1
• 
• when the concentration of ethanol is high then ethanol is oxidised by MEOS into acetaldehyde after tgat it is converted into acetate in the presence of aldehyde dehydrogenase and NADPH is converted into oxidised NADP+ in both reaction .
• When concentration of ethanol is low than it is oxidised into acetaldehyde during this reaction NAD+ is converted into NADH and further acetaldehyde changes into acetate .

◆ effect on changing the NAD+ / NADH :-. 【 REFER TABLE 2 】

• ​​​​​​when the concentration of NADH / NAD+ increases then
  • ​​​​​​​ gluconeogenesis is inhibited and increase the process of glycolysis this leads to severe hypoglycemia or loss of conciousness
  • increase concentration of pyruvate and converted into lactate this leads to lactic acidosis
  • decrease fat breakdown and increase fat synthesis leads to fatty liver .