Question

947.Ethanol metabolism in the liver results in the increase of the NADH/NAD⁺ ratio in the liver cytosol.

946.In gluconeogenesis, the regulatory enzyme fructose 1,6-bisphosphatase is inhibited by AMP.

945.Glucose-6-P dehydrogenase deficiency can lead to drug-induced hemolytic anemia because not enough NADH is generated.

944.Glucagon and epinephrine are similar in that both promote glycogenolysis.

943.Phosphofructokinase activity can be decreased by AMP.

942.Protein phosphatase can reverse the action of the kinase on enzymes.

Answer 1

947.Ethanol metabolism in the liver results in the increase of the NADH/NAD+ ratio in the liver cytosol.- true

Explanation- Consumption and metabolism of ethanol causes high levels of NADH in the cytosol and mitochondria of the liver cell. Alcohol is oxidized in the cytosol of hepatocytes by alcohol dehydrogenase (ADH), which generates NADH and increases cytosolic NADH/NAD+ ratio.

946.In gluconeogenesis, the regulatory enzyme fructose 1,6-bisphosphatase is inhibited by AMP.- true

Explanation- Fructose-1, 6-bisphosphate is an essential regulatory enzyme in gluconeogenesis and has long been
considered as a drug target towards type II diabete. AMP is an allosteric inhibitor that binds to FBPase with positive coopertivity, and Fru-2,6-P2 is an active site inhibitor which is up-regulated by hormone.

945.Glucose-6-P dehydrogenase deficiency can lead to drug-induced hemolytic anemia because not enough NADH is generated.- true

Explanation- When severe G6PD deficiency complicates malaria infection, treatment with primaquine or dapsone can lead to life-threatening acute intravascular hemolysis followed by anemia and acute renal failure

944.Glucagon and epinephrine are similar in that both promote glycogenolysis.- true

Explanation- Glycogenolysisis the breakdown of the molecule glycogen into glucose. Glucagon and epinephrine trigger the breakdown of glycogen. Epinephrine stimulates glycogen breakdown in muscle and, to a lesser extent, in the liver. The liver is more responsive to glucagon, a polypeptide hormone that is secreted by the α cells of the pancreas when the blood-sugar level is low.

943.Phosphofructokinase activity can be decreased by AMP.- false

Explanation- . PFK catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate in glycolysis. PFK is inhibited by ATP and citrate and positively regulated by AMP.

942.Protein phosphatase can reverse the action of the kinase on enzymes.- true

Explanation- Protein serine/threonine phosphatases are enzymes that reverse the actions of protein kinases by cleaving phosphate from serine and threonine residues in proteins.

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