Question

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Jan is a 28-year-old Clinical Laboratory Science college student. She is married and has 3 young children. She leads a very stressful life and has a history of stomach ulcers. Jan has been on the following medications for many years:

• Prilosec (a proton pump inhibitor for acid reflux)
• Depo Provera (birth control which is injected every 3 months)

She is concerned because her mother developed osteoporosis at a young age and is worried she may develop the same condition. Is she a candidate to develop the disease based upon this information given?

Please select the single best answer

	No, she appears to be healthy
	Yes, her medication use is setting her up for decreased calcium absorption which may decrease bone mass.
	No, her mothers history does not play a role as osteoporosis is not known to be hereditary
	Yes, her young age and 3 pregnancies puts her at significant risk.

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A pain management patient has been prescribed hydrocodone. His most recent drug test shows hydrocodone at 145 ng/mL and hydromorphone at 550 ng/mL. Hydromorphone is a metabolite of hydrocodone and is generally detected at a concentration lower than hydrocodone. Assuming the patient is taking his prescription as prescribed, what is the most reasonable explanation for the discrepancy seen in these results?

Please select the single best answer

	The patient is taking Lexapro, an SSRI that is known to inhibit CYP enzymes.
	The patient is using Capsaican, an inhibitor of CYP enzymes.
	The patient is taking dexamethasone, a corticosteroid known to induce CYP enzymes.
	The patient has been eating Brussel sprouts, an inducer of CYP enzymes.

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Which of the following statements are true relative to non-specific dyes used for detection in the RT-PCR procedure? More than one answer may be correct.

More than one answer is correct. Please select all correct answers

	These dyes are fluorescent and bind to all pieces of double-stranded DNA.
	SYBR green is an example of a non-specific dye.
	TaqMan is a widely-used, non-specific dye technique employing a cyanine dye.
	Non-specific dyes can potentially cause inaccurate quantification.

Answer 1

Answer: The word Osteoporosis means spongy (porous) bone. It is a bone disease that occurs when the body loses too much bone,makes too little bone,or both.As a result,bones become weak and may  break from a fall or in serious cases,from sneezing or minor bumps.

The single best answer for Jan’s condition is

Yes,her medication use is setting her up for decreased calcium absorption which may decrease bone mass.

Prilosec is a proton pump inhibitor.Proton pump inhibitors are drugs that are used to treat acid- related diseases such as reflux,heartburn and ulcers.These drugs reduce the amount of acid produced in the stomach. Long - term use ( several years) of proton pump inhibitors,can cause less calcium absorption from foods in the presence of lower stomach acid.

Depo - Provera: When used for contraception,the long- term use of injectable Depo- Provera has been shown to result in a significant reduction in bone mineral density.Most of this bone loss is reversible after the dru is discontinued.

Jan has been taking both Prilosec and Depo - Provera medications for  many years.So chances are for developing drug induced osteoporosis.