In: Biology
A patient comes to you complaining about her inability to digest fats properly. She would like you to explain to her how fats, carbs, and proteins are digested.(Answer in detail please)
i. Inability of digestion of fats properly in the given case would be due to deficiency of lipase, bile salts deficiency, malabsorption or fatty acid metabolism disorder.
ii.
a. Digestion of fats:
Area | Juice | Enzymes | Substrates | End product |
Mouth | Saliva | Lingual lipase | Triglycerides | Fatty acid and 1,2 diacylglycerol |
Stomach | Gastric juice |
Gastric lipase (weak lipase) |
Triglycerides | Fatty acids and glycerol |
Small intestine | Pancreatic lipase | Pancreatic lipase | Triglycerides | Monoglycerides, Fatty acid |
Cholesterol ester hydrolase | Cholesterol ester | Free cholesterol and fatty acid | ||
Phospholipase A | Phospholipids | Lysophospholipids | ||
Phospholipase B | Lysophospholipids | Phosphoryl cholline, free fatty acids | ||
Succus entericus | Intestinal lipase | Triglycerides | Fatty acids and glycerol (weak action) |
b. Digestion of Carbohydrates:
Part of Gastrointestinal tract | Juice | Enzyme | Substrate | End-product |
Mouth | Saliva | Salivary amylase | Polysaccharides | Disaccharides-Dextin and maltose |
Stomach | Gastric juice | Gastric amylase | Weak amylase | Action is negligible |
Small intestine | Pancreatic juice | Pancreatic amylase | Polysaccharides | Disaccharides-Dextrin, maltose and maltriose |
Succus entericus | Sucrase | Sucrose | Glucose and fructose | |
Maltase | Maltose and maltriose | Glucose | ||
Lactase | Lactose | Glucose and galactose | ||
Dextrinase | Dextrin, maltose and maltriose | GLucose | ||
Trehalase | Trehalose | Glucose |
c. Digestion of proteins:
Part | Juice | Enzyme | Substrate | End product |
Mouth | Saliva | No proteolytic enzyme | --- | ---- |
Stomach | Gastric juice | Pepsin | Proteins | Proteoses, Peptones, Large polypeptides |
Small intestine | Pancreatic juice | Trypsin | Proteoses and peptones | Dipeptides, tripeptides, polypeptides |
Chymotrypsin | ||||
Carboxypeptidases A and B | Dipeptides, tripeptides, polypeptides | Amino acids | ||
Succus entericus | Dipeptidases | Dipeptides | Amino acids | |
Tripeptidases | Tripeptides | |||
Amino peptidases | Large polypeptides |
So, the end products of digestio are glucose (from carbohydrates), amino acids (from proteins) and fatty acids and glycerol (from lipids)