In: Chemistry
explain how the oxygen's affinity to hemoglobin changes in your lungs. What happens to N-carbomates and to Bohr's protons all that moment? What changes take place in hemoglobin itself?
Bohr effect
Chagne of Bohr Protons at lungs
Oxygen Transport at lungs
When blood nearer to the lungs, the carbon dioxide concentration decreases, which increases the pH.
This increase in pH increases hemoglobin's affinity for oxygen binding through the Bohr effect. Therefore hemoglobin picks up oxygen from the lungs and transport it to the tissues.
In the tissues, the increasing CO2 concentration decreases the pH, which helps hemoglobin to dump the oxygen in the tissues
The pH-mediated change in affinity for oxygen helps hemoglobin act like a shuttle that picks up oxygen in the lungs and deposits it in the tissues where it will be needed
Shape of Hemoglobin when it binds with oxygen
Heme group is nonplanar when it is not bound to oxygen; the iron atom is pulled out of the plane of the porphyrin ring.
This nonplanar configuration is characteristic of the deoxygenated heme group, and it is termed as "domed" shape
When the Fe in the heme group binds to an oxygen molecule, the porphyrin ring adopts a planar configuration and hence the Fe lies in the plane of the porphyrin ring