True or False 41. _____ Gleevec is an anticancer drug that functions by blocking the kinase...

True or False

41. _____ Gleevec is an anticancer drug that functions by blocking the kinase activity of Bcr-Abl.

42. _____ All of the cells in a primary tumor are thought to be descendants of a single abnormal cell.

43. _____ A malignant or invasive carcinoma is characterized by its ability to breach the basement membrane.

45. _____ Missense mutations are rarely found in oncogenes.

46. _____ Intracellular signaling pathways can activate integrins by promoting the association of talin with the integrin bchain.

Expert Solution

Ans 41:- True

explanation:- Gleevec (imatinib) competitively bind to active site of bcr-alb by which it inhibit substrate binding and cancer cell can not grow and proliferate.

Ans 42:- True

explanation:- all primary tumor arise from single abnormal cell as mutation in one cell lead to uncontrolled cell growth which ultimately form primary tumor.

Ans 43:- True

explanation:- at some stage tumor cell secret substances that degrade basement membrane and it is important for spread of cancer cell to other tissues and organ this process is called metastasis.

Ans 45:- True

explanation:-missense mutation is also called as point mutation in which one different nucleotide results in different amino acid lead to non functional resulting protein. this mutation mainly responsible for disease like sickle cell anaemia.

Ans 46:- True

explanation:- Integrin is required for communication between intracellular cytoskeletal to extra cellular matrix. this communication plays essential role in cell migration and cell adhesion. talin is protein found as cell adhesion site. it consist of talin-H (head) and talin-R (rod). talin H consist of dour domain F0, F1, F2, F3. on intra cellular signal talin head bind to beta chain of Integrin and activate it.

gladiator answered 2 years ago

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