Discuss briefly the phenomenon of inheritance by Epigenetic theory.
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Expert Solution
Epigenetic theory:
In 1759 a German zoologist C.F. Wolff (1738-1794) proposed that neither the egg nor the sperm had a structure like homunculus (preformed embryo) but that the gametes contained undifferentiated living substance capable of forming the organized body after fertilization.
He advocated that the future embryonic regions of an egg first consist of granules or 'globules' (viz., cells or their nuclei) which gradually organize into rudiments (germinal layers) that, in turn, took on the characteristics of the various organs of the embryo.
This method of progressive development from the simpler to the more complex through the utilization of building units (globules or cells) is called epigenesis.
Epigenetic theory:
The study of how the behavior and environment cause changes which affect the way the genes work is defined as the Epigenetics.
These epigenetic changes are reversible and do not change the DNA sequence, but they can change how the body reads a DNA sequence.
(a) In the space below, compare and contrast the terms
'epigenetic modification' and 'epigenetic inheritance'.
(b) Can epigenetic inheritance be studied in a dividing
unicellular eukaryote such as yeast? Why or why not?
(c) Epigenetic modification of histones and epigenetic
modification of DNA by DNA-methylation have some conceptual
similarities as well as differences. For example, both have enzymes
that can add or remove chemical modifications. Of the classes of
DNA methylation enzymes below, circle the one that allows the
pattern...
ARE THESE STATEMENTS TRUE OR FALSE:
1. Epigenetic changes to the DNA are passed down to the
offspring, however, they do not cause changes to the genes, or
alleles. Is this statement true or false?
2.Genes are located on chromosomes. Is this statement true or
false?
3. If someone with type B blood has children with
someone who is type A blood, is it possible for them to have a
child that is type O? YES OR NO?
The structure of chromatin at the centromeres is passed on to
daughter cells through epigenetic inheritance, meaning without any
input from the DNA sequence. Explain how this
occurs.
comment on the significance of RNAi for understanding epigenetic
control of the human genome. In particular, respond to this
statement: "RNAi provides an attractive model to explain how
epigenetic histone modifications are targeted to specific genomic
loci".
Which of the following is NOT an epigenetic stimulus/marker used
to package DNA?
Select one:
- Ubiquitination
- Methylation
- Phosphorylation
- Acetylation
Epigenetic effects on gene expression may occur through
covalent modifications of ____ and _________.
Overexpression of ___________, which bind to and silence mRNAs,
may lead to the development of cancer.
Precarcinogens are themselves not carcinogens but may be
modified in the liver to become a carcinogen by a process known as
__________ __________.
Nude mice are useful for investigating cancer cells because the
nude mice lack a functional _______ system.
What are the main epigenetic mechanisms that interfere with the
expression of genes?
CRCs (chromatin remodeling complexes) drive the formation of
heterochromatin regardless of any regulatory input.
CRCs condense chromatin in centromeres, telomeres and origins of
replication. gene-rich genomic DNA regions that are not condensed
by CRCs (chromatin remodeling complexes) are able to be accessed by
transcription factors that may activate or repress transcription
(gene expression).
CRCs (chromatin remodeling complexes) locally (regionally)
reorganize global chromatin structure making it inaccessible (by...