Question

The plant alkaloid, Vinblastine, is used to treat a number of types of cancer. It causes depolymerization and destabilization of microtubules. In which of the following cell cycle stages, would treated human cells be most likely arrested or stopped?

options:

S

M

G2

G1

Answer 1

Ans: M

Explanation: Vinablastin is a set of alkaloids agents ie, antimitotic or antimicrotubule called vinca alkaloids. It is derived from the periwinkle plant Catharanthus roseus. Vinblastine inhibits the gathering of microtubules by binding to these tubules. Vinblastine treatment mainly acts in the M phases of the cell cycle, because in this phase proper formation of mitotic spindle fibres occurs with kinetochore. Vinblastine binding to tubules and inhibit the gathering microtubules during M phase of the cell cycle. Each of these formations in M phase is essential for the chromosomal separation in Anaphase of the cell cycle.
Vinblastine is one of the drugs is used in chemotherapy. It is used in the treatment of lungs cancer, brain cancer, Hodgkin's lymphoma, bladder cancer, testicular cancer and melanoma. Vinblastine is directly injected into the vein.
There are various side effects of vinblastine experienced by people: Constipation, shortness of breath, weakness, low blood cell count, headache and loss of appetite.