Phenylketonuria is a recessively inherited disease. A woman and her husband do NOT have the disease...

Phenylketonuria is a recessively inherited disease. A woman and her husband do NOT have the disease yet their daughter has the disease. If the couple has a total of 3 children how likely is it: that all 3 children will have the disease? and that at least one child will NOT have the disease? (PLEASE INCLUDE LEGENDS, PUNNET SQUARES and show work)

Expert Solution

Answer: Phenylketonuria (PKU) is an autosomal recessive disease due to mutation of the PAH gene located at 12q^24.1. The normal function of this gene to synthesise protein enzyme that is phenylalanine hydroxylase (PAH). This PAH enzyme hydroxylates phenylalanine to tyrosine. Since it is an autosomal recessive disease so disease appears in the presence of homozygous defective alleles of this gene.

If the child of any couple is suffering from this disease and they do not have the disease means they are the carrier of this disease. For genetics and the combination of all the possible sets of the gene, only one is affected by this disease out of 4 from their carrier parents (see detail in figure below).

So it is not possible that all three children’s will be affected by this disease. The resultant probability for the occurrence of all three children is (0.25)³. That is 0.0156%.

So 0.0156% is the chance for occurrence of all three children suffering from this disease. Not the chance for the occurrence of the disease is 1- 0.0156 = 0.98%.

gladiator answered 1 year ago

There is a woman, she is married, but her husband abandoned her. It has been a...

There is a woman, she is married, but her husband abandoned her. It has been a year but never divorced. They have two children. She has a job, she lives with her parents during work, her parents There is a big house, her parents didn’t charge her any rent, and most of her money is spent on food and children. Question 1: will she qualify for a household Question 2: preparing her tax return what should you say to her?...

A psychologist treating an adult woman for bulimia, with the patient’s permission, invited her husband to...

A psychologist treating an adult woman for bulimia, with the patient’s permission, invited her husband to participate in family therapy sessions where the focus was on the woman’s health. Whether the husband was currently in therapy with another professional was not an issue because the reason he had been approached was to participate in therapy where the wife was the identified patient. Is this scenario Ethical or Unethical? If Ethical select True or Unethical select False. A psychologist developed a...

1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene...

1. Phenylketonuria (PKU) is an inherited disorder in which a mutation in a single autosomal gene leads to inability to break down the amino acid called phenylalanine. Babies born with PKU often have the following symptoms: a musty odor to the skin, hair, and urine; vomiting and diarrhea; irritability; itchy skin, and sensitivity to light. If this condition goes untreated, it can lead to the loss of skills, growth and developmental delays and seizures. The term that best fits with...

Mrs. S is a 49-year-old woman with end-stage cardiomyopathy. She and her husband have been restaurant...

Mrs. S is a 49-year-old woman with end-stage cardiomyopathy. She and her husband have been restaurant owners for many years. She is anorexic and finds it difficult to eat solid foods, which is emotionally distressing for her and her family. She has lost 10 lb in the past month. Mrs. S was placed on the heart transplant list 6 months ago. She has agreed to hospitalization to optimize her medical management and nutrition status. Clinical Assessment Mrs. S is admitted...

You are preparing an 81 year old woman for discharge following a stroke. her husband will...

You are preparing an 81 year old woman for discharge following a stroke. her husband will be the caregiver. what teaching might you to provide to prepare him for the caregiver role

Mrs. Giammo is a 59-year-old woman who was brought to the emergency department by her husband....

Mrs. Giammo is a 59-year-old woman who was brought to the emergency department by her husband. Mr. Giammo noticed that all of a sudden his wife "was slurring her speech and her face was drooping on one side." Mrs. Giammo told her husband that she felt some numbness on the right side of her face and in her right arm. Mr. Giammo was afraid his wife was having a stroke so he brought her to the hospital. Case Study In...

A.J. is a 63-year-old white woman who is brought to the emergency department by her husband....

A.J. is a 63-year-old white woman who is brought to the emergency department by her husband. She has become progressively weaker and was admitted for further evaluation. Subjective data: complains of progressive weakness over the last couple of weeks, has had a recent sinus infection that resolved after two courses of antibiotics, complains of shortness of breath, has noticed a lot of bruising lately Objective data: Physical exam: Has scattered petechiae on both ankles and two ecchymoses on her arms...

Ruba is a 39 years old, pregnant woman at 8 weeks gestation, and her husband, Ali,...

Ruba is a 39 years old, pregnant woman at 8 weeks gestation, and her husband, Ali, is 50 years old, arrives at antenatal clinic for follow-up. The couples have been married for 12 years. Ruba completes the initial paperwork, and the nurse notes the following obstetric history: G6 T0 P0 A5 L0 M0. Ruba and Ali asked the nurse many questions regarding Down syndrome as Ali’s sister, recently, has a boy with Down syndrome. 1. What are the questions in the...

Using property she inherited, Myrna makes a gift of $16.2 million to her adult daughter, Doris. Neither Myrna nor her husband,

Using property she inherited, Myrna makes a gift of $16.2 million to her adult daughter, Doris. Neither Myrna nor her husband, Greg, has made any prior taxable gifts. Assuming that a flat 40% tax rate applies, determine the Federal gift tax liability if: a. The election to split gifts is not made. b. The election to split gifts is made. c. What are the tax savings from making the election?

Edith Johnson owned a used Jayco brand pop-up camper that she inherited when her husband, Mark,...

Edith Johnson owned a used Jayco brand pop-up camper that she inherited when her husband, Mark, passed away last year. Edith advertised the pop-up camper for sale in a local newspaper for $5,000 or best offer. Eric Young, seeing the ad and in the market for a camper, responded to the ad and met with Edith at her home to inspect the camper. After some discussion, the Eric proposed to pay Edith $4,500 for the trailer, as-is, with a deposit of $500...

Question