Which of the following statements about DNA repair is correct Group of answer choices during excision...

Which of the following statements about DNA repair is correct

Group of answer choices

during excision repair, an exonuclease is the first enzyme involved in removing a single-stranded segment of DNA from the template strand

none of the answer is correct

during mismatch repair, a methylated guanine in the consensus sequence GATC found on the parent strand activates the Mut complex

the Okazaki fragments synthesized during base excision repair are synthesized in a 3’ -- > 5’ fashion

repair of methylated DNA requires a set of proteins operating with the following order: endonuclease, exonuclease, DNA polymerase I, ligase and demethylase

Solutions

Expert Solution

Statement 1:" During excision repair, an exonuclease is the first enzyme involved in removing a single-stranded segment of DNA from the template strand"

is False because in Base excision repair GLYCOSYLASE is the first enzyme that recognizes and removes the damages base by hydrolyzing glycosidic acid. And the resultant basic sugar is being removed from DNA backbone by endonucleolytic step.

Statement 2:" none of the answer is correct"

is also False

Statement 3: "during mismatch repair, a methylated guanine in the consensus sequence GATC found on the parent strand activates the Mut complex"

is False because the consensus sequence GATC is methylated at Adenine and not Guanine.Also, the newly synthesized strand is hemimethylated which when replicated synthesize a strand that lacks methyl group which gets recognized and bind to Mut H , which recruit MutL and MutS and then after activates Mut complex.

Statement 4: "the Okazaki fragments synthesized during base excision repair are synthesized in a 3’ -- > 5’ fashion"

is False because DNA polymerase is unidirectional and synthesis of new strand always occurs in 5' to 3' direction even for Okazaki fragment synthesis during base excision repair.

Statement 5: "repair of methylated DNA requires a set of proteins operating with the following order: endonuclease, exonuclease, DNA polymerase I, ligase and demethylase"

is True because in case of Ecoli ,sequence GATC is widely distributed on entire genome and repair of these DNA uses protein in the order

Endonuclease to create nick in the unmethylated strand

Exonuclease to remove ssDNA between nick and mismatch.

DNA polymerase to remove mismatch .Followed by ligase and demethylase

So statement 5 is correct.

gladiator answered 1 year ago

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