Assume that you identify a set of conditions under which glycolysis and gluconeogenesis occur in parallel...

Assume that you identify a set of conditions under which glycolysis and gluconeogenesis occur in parallel and at the same rate. What do you expect in terms of the net energetics of this system?

Group of answer choices

neither gain nor loss of high energy bonds

loss of four high energy bonds

gain of three high energy bonds

gain of one high energy bond

loss of two high energy bonds

Solutions

Expert Solution

It will result in the loss of four hig energy bonds. In the form of 2 ATP and 2GTP. This is because one round of glycolysis produces 4 ATPs from which two are consumed in the energy investment phase of glycolysis. And for the gluconeogenesis first one ATP will be lost to conver one mole pyruvate to oxaloacetate and then one GTP will be lost for conversion of oxaloacetate to phosphoenol pyruvate. Then in the conversion of 3-phosphoglycerate to 1,3-bisphosphoglycerate another ATP will be consumed. And as we know one mole of glucose generates 2 moles of pyruvate there fore a total of 4 ATPs and 2 GTPs will be consumed. In contrast as we know glycolysis generates 2 ATP there fore there be a total loss of 2 ATPs and 2 GTPs.

The overall reaction of glycolysis is-

Glucose+2ADP+2Pi+2NAD+ --> 2 Pyruvate+2 ATP+ 2NADH+ 2H+.

The overall reaction of gluconeogenesis is-

2 Pyruvate+4ATP+2GTP+2NADH+2H+ + 6H2O --> Glucose+ 2NAD+ + 4ADP+2GDP+6Pi+6H+.

gladiator answered 1 year ago

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