Question

How does Clostridium difficile infect individuals who would otherwise be considered healthy?
In what ways can drug resistance C. difficile be treated and how is it more beneficial compared to conventional treatment options for bacterial pathogens?
It's major toxin Clostridial difficile Toxin A, is an AB toxin that induces diarrhea and epithelial barrier damage. Which steps of the pathogenic process could this toxin benefit colonization and (re)colonization of patients with C. difficile.

Answer 1

Ans- Clostridium diffcile bacteria are found the environment in soil, air, water, human and animal feces and processed meat. A small number of healthy people naturally carry the bacteria in their large intestine and don't have ill effects from infection.

When you take an antibiotic to treat any infection, these drugs tend to destroy some of normal, helpful bacteria,in addition to the bacteria causing the infection without enough healthy bacteria to keep it in check, Clostridium diffcile can quickly grow out of control. The antibiotics that most pfoft lead to Clostridium difficile infection that is diarrhoea and other intestine infection. Treatment- Standard treatment for Clostridium difficile is another antibiotic. These antibiotic keep Clostridium diffcile from growing which in turn diarrhoea and other complications.

Clostridium difficile has a different time colonizing on its own, but it can be found as part of the normal gut. Once a patient has taken broad spectrum antibiotics, Clostridium diffcile takes advantage of the lack of commensal bacteria in order to colonize the large intestine. Toxin A and B distrupt the actin cytoskeleton of fibroblasts and prevent cells from being able to regulate actin polymerization. Toxin B is 10 times more potent than A in causing damage in colonic epithelial cells.