CF carrier frequency estimations in American Hispanic populations • Carrier screening kits for Cystic Fibrosis alleles...

CF carrier frequency estimations in American Hispanic populations • Carrier screening kits for Cystic Fibrosis alleles have been updated to include more probes (CFTR 60 kit 2) • It is reported to have a detection rate of 83.7% in Hispanic American populations.

The same group have a CF incidence of 1 in 9,500. Given the above, determine:

1) CF carrier frequency in the Hispanic American population.

2) Estimate the probability of being a carrier if a CFTR 60 kit result is negative for a member of this population.

3) Estimate probability of a child with CF being born if one parent is a known CF carrier and the other is Hispanic and found to be negative when tested with the CFTR 60 kit.

Expert Solution

1.Frequency of CF carrier individual in the Hispanic American population is 1.98%

2.Probability of being carrier is 16.3% , if a CFTR 60KIT result is negative .

3. One parent is known CF carrier (Ff) . The chance of transmitting the recessive allele to the offspring by this parent is 50%.

Another parent is negative according to CFTR 60 kit test. 16.3% chance is there that he/she is a carrier. So there is (16.3/2) 8.15% chance that the offspring will get recessive allele from this parent.

So the Probability of the child will have cystic fibrosis is =

(50% × 8.15% )×100 = 4.07%

gladiator answered 1 year ago

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CF carrier frequency estimations in American Hispanic populations • Carrier screening kits for Cystic Fibrosis alleles...

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