Question

In: Anatomy and Physiology

You are a researcher interested in studying Schwann cell development. It is known from prior work...

You are a researcher interested in studying Schwann cell development. It is known from prior work that Schwann cells express the protein Sox10. You decide to create a transgenic fish line to label the Schwann cells. Explain how you would create the transgenic embryos. Be as detailed as possible.

Solutions

Expert Solution

* Transgenic embryos are created by genetic manipulation of host species that carry exogenous genetic material or genes from other species in their genome.

* This technique is used to introduce new genes or genes of interest into strains of laboratory to study function and pathology regarding specific gene.

* Fish is the first genetically modified animal to be used for consumption in humans.

* The fish is essentially an Atlantic salmon with single gene complex inserted, a growth hormone regulating gene from chinook salmon with a promoter sequence.

* The aim is to introduce new trait to fish that before does not occur in nature as a species. This process is called trans genesis.

* Genetically modified fish are developed as environmental pollutant sentinels and also used in aquaculture for production of food.

Transgenic fish are used in research centers

* Indicators of aquatic pollutants.

* used in functional genomic studies.

* Development in biomedical use as reactors for important proteins, used in cardiovascular diseases etc.


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