Question

what is the importance of oxopiperazine

Answer 1

Therapeutic uses

1. Valdivielso et al., has established the PAR1 antagonists properties of 2-oxopiperazine analogues.

2. They are crucial in peptidomimetic chemistry. In peptide backbone, they attach the Ni and Ni-1 positions. They are useful in imparting pharmacological and pharmacokinetic properties.

3. Kitamura et al has established the 2-oxopiperazine derivatives as GPIIb/IIIa antagonists. This particular molecule was found to prevent platelet aggregation.

4. Molecules like agelastatine A, marcfortine B are having oxopiperazine ring.

References:

1. http://digital.csic.es/bitstream/10261/101413/4/Eur%20J%20Med%20Chem-2013.pdf

2. http://www.cnr.it/istituti/Allegato_83021.pdf?LO=01000000d9c8b7a60900000009000000db9b0000c52f9c53000000000100000000000000000000000000000000000000000000000000000000000000000000000000000000000000&type=application/pdf

3. http://pubs.acs.org/doi/abs/10.1021/jm0004345

4. http://www.davidpublisher.org/Public/uploads/Contribute/56248c135898a.pdf