Question

In: Biology

10. There are a total of five different melanocortin receptors that are expressed in various tissues...

10. There are a total of five different melanocortin receptors that are expressed in various tissues of the human body. MC1R is, however, the only family member expressed in melanocytes. Using no more than one short paragraph (max 5 sentences) describe, from a molecular perspective, how MC1R but not the other MCRs are expressed in melanocytes.  

Solutions

Expert Solution

The melanocortin 1 receptor (MC1R) is a G protein-coupled receptor crucial for the regulation of melanocyte proliferation and function. Upon binding melanocortins, MC1R activates several signaling cascades, notably the cAMP pathway leading to synthesis of photoprotective eumelanin. Polymorphisms in the MC1R gene are a major source of normal variation of human hair color and skin pigmentation, response to ultraviolet radiation (UVR) and skin cancer susceptibility. The identification of a surprisingly high number of MC1R natural variants strongly associated with pigmentary phenotypes and increased skin cancer risk has prompted research on the functional properties of the wild-type receptor and frequent mutant alleles. We summarize current knowledge on MC1R structural and functional properties, as well as on its intracellular trafficking and signaling. We also review the current knowledge about the function of MC1R as a skin cancer, particularly melanoma, susceptibility gene and how it modulates the response of melanocytes to UVR.


Related Solutions

Let's say there is a group of five receptors (A1,A2,A3,A4,A5) that are expressed in various types...
Let's say there is a group of five receptors (A1,A2,A3,A4,A5) that are expressed in various types of tissues on the human body. But the A1 receptor, is the only family expressed in 1 type of cell. How does the A1 receptor but not the other A receptors are expressed on the cell?
Given the expression profile of CFTR (tissues in which it is normally expressed) in non-affected individuals...
Given the expression profile of CFTR (tissues in which it is normally expressed) in non-affected individuals and what you know about CFTR function and membrane transport, how would dysfunctional CFTR lead to each of the following common cystic fibrosis symptoms? Use proper terms and include specific information relevant to membrane transport in your explanations. a.Thickened mucus of the lungs, pancreas, and GI tract b.Increased bacterial infections of the lungs c. Poor growth and malnutrition
what are the different muscular tissues their functions and location
what are the different muscular tissues their functions and location
Epinephrine and glucagon bind to different receptors on cell surface, but both receptors activate the same...
Epinephrine and glucagon bind to different receptors on cell surface, but both receptors activate the same G protein and trigger the same series of events in which cAMP is produced and activates downstream proteins to regulate the metabolism of different types of carbohydrates. In lecture, we have learnt that activation of G protein by these two hormones promotes the breakdown of glycogen through the activation of glycogen phosphorylase and inhibition of glycogen synthetase in liver and muscle. In this essay,...
The heating bills for a selected sample of houses in five different cities using various forms...
The heating bills for a selected sample of houses in five different cities using various forms of heating are given below (values are in dollars). City Gas Heated Homes Central Electric Heat Pump Ankara 83 90 81 Konya 80 88 83 Çorum 82 87 80 Yozgat 83 82 82 Kırşehir 82 83 79 Is there a significant difference among the average bills of the homes according to the different heating methods? Test at 10% significance level by using one-way ANOVA...
Critically discuss the different stages of an SME together with five various key types of funding....
Critically discuss the different stages of an SME together with five various key types of funding. In your discussion include which type of funding is most appropriate for each particular life-cycle stage of an SME.  
Consider the direction of collagen and elastin in various connective tissues. Also consider the amount of...
Consider the direction of collagen and elastin in various connective tissues. Also consider the amount of ground substance containing GAG's and proteoglycans. Answer the questions below regarding: Dense regular connective tissue, Considering the amount of collagen fibers vs elastic fibers, does the tissue you have chosen allow for a lot of distraction and does it rebound to its original shape, or does it simply prevent stretching of the tissue?
1. "compare the fate of the various reproductive tissues under the influence of testosterone or estrogen."...
1. "compare the fate of the various reproductive tissues under the influence of testosterone or estrogen." 2. "Describe the events of lactation including roles of hormones in milk production and release."
1. "compare the fate of the various reproductive tissues under the influence of testosterone or estrogen."...
1. "compare the fate of the various reproductive tissues under the influence of testosterone or estrogen." 2. "Describe the events of lactation including roles of hormones in milk production and release."
Discuss the different types of muscle tissues and their location and function in the body.
Discuss the different types of muscle tissues and their location and function in the body.
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT