Question

In: Anatomy and Physiology

1.) What is the importance of acetylcholinesterase in the neuromuscular junction? A. it breaks down acetylcholine...

1.) What is the importance of acetylcholinesterase in the neuromuscular junction?

A. it breaks down acetylcholine immediately after the neurotransmitter signals a contraction
B. it breaks down acetylcholine to signal the muscle fiber to extend
C. it ensures that multiple twitches are produced from a single stimulation
D. it prevents stimulation of muscle fibers


2.) In a sarcomere, the thin filaments are ______.

A. composed of slow oxidative fibers
B. the central part of an A band
C. the portion of a sarcomere that creates the dark-staining portions of the striations
D. the region made of myosin filaments
E. the region where calcium ions bind


3.) Rhabdomyolysis is ______.

A. an inherited sex-linked recessive disorder of muscle weakness leading to death
B. a mysterious chronic pain syndrome of unknown cause that results in fatigue
C. a condition in which myoglobin pours crushed muscle tissue into the bloodstream, causing renal failure
D. a common pain syndrome by tightened bands of muscle fiber

Solutions

Expert Solution

1. it breaks down acetylcholine immediately after the neurotransmitter signals a contraction.

Acetyl choline is a neurotransmitter release from pre synaptic neuron into the synaptic cleft,which bindes to the Acetyl choline receptors in the post synaptic neuron.This binding is essential for depolarisation of post synaptic membrane and occurance of muscle contraction.

Acetyl choilne esterase are the Enzymes that breakdown acetyl choline,Soon after the Muscle contraction occur,SO that repeated stimulation of post synaptic neuron by same acetyl choline molecule will not occur.

2.Option E-The region where calcium ions bind

In a Relaxed muscle,Tropomyosin molecules masks the Myosin binding Site on actin molecule.But During Stimulus,When action potential Reach the Motor End plate,the released ca2+ Binds to Troponin molecules on the Actin molecules.This troponin molecules are in contact with Tropomyosin molecule,so Binding of Ca2+ on troponin molecule induces Change in shape of Troponin molecule so that Tropomyosin gets moved from the myosin binding sites on Actin molecule.

In a sarcomere Thin filaments are Made up of Actin molecules & thick filaments are made of Myosin molecules.

H zone is The central part of A band-This is the region of thick filaments which is not overlapped by the actin filaments.

Dark-staining portions of the striations are formed by thick filaments,Thin filaments forms light staining region.

3.C. a condition in which myoglobin pours crushed muscle tissue into the bloodstream, causing renal failure

Rhabdomyolysis is the condition in which there is breakdown of damaged skeletal muscle. Muscle breakdown will lead to the release of myoglobin((the protein that stores oxygen in your muscles) into bloodstream. Too much myoglobin in the bloodcan lead to kidney damage.


Related Solutions

Many pesticides work by inhibiting the action of acetylcholinesterase, the enzyme that normally breaks down acetylcholine...
Many pesticides work by inhibiting the action of acetylcholinesterase, the enzyme that normally breaks down acetylcholine within the neuromuscular junction. What effect would inhibition of acetylcholinesterase have on muscle tissue and why? What symptoms might you expect in cases of pesticide toxicity? What do you think is the most likely cause of death in these poisonings?
describe the neuromuscular junction. what is the function of the neuromuscular junction?
describe the neuromuscular junction. what is the function of the neuromuscular junction?
Describe what happens once acetylcholine is released from the synaptic end bulb into the neuromuscular junction....
Describe what happens once acetylcholine is released from the synaptic end bulb into the neuromuscular junction. Your explanation should explain everything that occurs during the muscle contraction.
Acetylcholinesterase catalyzes the hydrolysis of the neurotransmitter acetylcholine: Acetylcholine + H2O  acetate + choline The...
Acetylcholinesterase catalyzes the hydrolysis of the neurotransmitter acetylcholine: Acetylcholine + H2O  acetate + choline The Km of acetylcholinesterase for its substrate acetylcholine is 9.5x10-5M. In a reaction mixture containing 5 nanomoles/mL of acetylcholinesterase and 150μM acetylcholine, a velocity vo=40μmol/mLsec was observed for the acetylcholinesterase reaction. a. Calculate Vmax for this amount of enzyme b. Calculate kcat for acetylcholinesterase c. Calculate the catalytic efficiency (kcat/Km) for acetylcholinesterase d. Does acetylcholinesterase approach catalytic perfection? e. What determines the ultimate speed limit...
What is a neuromuscular junction? List and describe the junction. List and describe the roles of...
What is a neuromuscular junction? List and describe the junction. List and describe the roles of the chemicals involved at that site
The two types of neuromuscular junction are nondepolarizing neuromuscular blockers and depolarizing neuromuscular blockers. Constrict a...
The two types of neuromuscular junction are nondepolarizing neuromuscular blockers and depolarizing neuromuscular blockers. Constrict a table that compares and contrasts the therapeutic actions, indications, pharmacokinetics, contraindications, and important drug-drug interactions for each type of neuromuscular junction blocking agents.
What is the role of acetylcholinesterase at a synapse? It stimulates the post-synaptic neuron. It breaks...
What is the role of acetylcholinesterase at a synapse? It stimulates the post-synaptic neuron. It breaks down acetylcholine. It releases calcium ions. All apply.
Acetylcholine binds to what type of receptor? a. What does acetylcholinesterase do? b. What happens if...
Acetylcholine binds to what type of receptor? a. What does acetylcholinesterase do? b. What happens if acetylcholinesterase is inhibited (blocked)? c. Will ACh increase or decrease in the synapse? Increase because once the enzyme is eliminated, Ach will increase in production resulting in more responses What type of receptors do the following bind to? a. Epinephrine and norepinephrine b. Dopamine c. Serotonin d. Histamine i. How does a monoamine oxidase inhibitor work (MAO-I)? ii. How does a selective serotonin reuptake...
Physiologist discover a new disease affecting neuromuscular transmission at the neuromuscular junction NMJ. They called the...
Physiologist discover a new disease affecting neuromuscular transmission at the neuromuscular junction NMJ. They called the condition PLT disease and it causes weakness and increasing fatigue in the skeletal muscles, due to the production of antibodies that target membrane bound receptors of the skeletal muscle cells Part A How will the antibodies produced in PLT disease affect neuromuscular transmission? Identify the specific receptors on the skeletal muscle cells that will target these antibodies and the neurotransmitters involved Part B The...
Physiologists discover a new disease affecting neuromuscular transmission at the neuromuscular junction (NMJ). They have called...
Physiologists discover a new disease affecting neuromuscular transmission at the neuromuscular junction (NMJ). They have called the condition PLT disease and it causes weakness and increasing fatigue in skeletal muscles, due to the production of antibodies that target membrane-bound receptors of skeletal muscle cells. Using your knowledge of neurophysiology (M1) and the muscular system (M4), please answer the following questions below. Be sure to clearly label the different parts. PART A How will the antibodies produced in PLT disease affect...
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT