Question

In: Anatomy and Physiology

If a patient is infected with tapeworms and the tapeworms are located in her brain, why...

If a patient is infected with tapeworms and the tapeworms are located in her brain, why does giving them a steroid (prednisone) temporarily make them better but then make it worse?

Solutions

Expert Solution

Tapeworms infect humans through uncooked food such as pork. The adult will divide and will produce proglottids in small intestine. These proglottids contain ova of the tapeworm are released in the feces and can be ingested by animals. Upon ingestion by animals, they will be converted to cysts in muscles and brain of the infected animals. Ova ingested by humans from infected meat can lead to infection in humans. The tapeworm can also infect the brain in humans and cause massive inflammation in the CNS.

Cysts are present in the brain parenchyma causing obstruction of ventricles of brain and inflammation and also cause seizures. Some cysts can grow abnormally large and infiltrate the spaces in brain and spinal cord, which leads to meningitis. Inflammation in the brain due to cysts is called neurocysticercosis (NCC). Inflammation is a result of degeneration of the tapeworms due to immune attack. This inflammation is mostly due to eosinophil infiltration.

Prednisone is a corticosteroid hormone that is known to decrease inflammation. Corticosteroids reduce inflammation in the brain and are used in NCC. Prednisone is prescribed as treatment of brain inflammation in NCC. Prednisone will decrease the migration of polymorphonuclear leukocytes to the site of infection. It also reverses the permeability in the capillaries, leading to decreased inflammation. Further, prednisone is also known to suppress immune attack. All these effects of prednisone are mediated via glucocorticoid receptors present. The signaling results in reduced production of mediators of inflammation.

Prednisone has a major side effect of affecting the immune system as well. Further, it will also decrease any inflammatory process that occurs in the body. This decreases the ability of the body to fight infection. It also creates side effects such as hyperglycemia, insomnia, and increases appetite> There is increase in hypertension, suppression of adrenal glands and osteoporosis. Thus, initially the infected individual feels better due to decreased inflammation in the brain caused by tapeworm infection. However, with long term treatment, the side effects will increase. Hyperglycemia will cause decreased utilization of the blood sugar, making the person feel fatigued. The other side effects will also add to the general unwell feeling by the person.


Related Solutions

why are tapeworms in a class of their own?
why are tapeworms in a class of their own?
Why would surgery be done on a patient with a brain tumor
Why would surgery be done on a patient with a brain tumor
1. A right-handed split-brain patient is asked to assemble blocks to match a pattern located in...
1. A right-handed split-brain patient is asked to assemble blocks to match a pattern located in the upper left-hand corner. If they are asked to do this using their right hand, they will: have a very difficult time performing the task. not understand the instructions. be able to perform the task easily. refuse to perform the task. 2. Active touch information, or sensory information from one side of the body going to the opposite hemisphere, is often called: contralateral innervation....
In this case study, an elderly patient has kidney cancer that has metastasized to her brain,...
In this case study, an elderly patient has kidney cancer that has metastasized to her brain, making her permanently unconscious. Dialysis could help keep her alive for 6-9 months and an experimental drug might help her cancer. Her insurance does not cover the drug and it will deplete her savings. what should she do? - biblical back up -200 words
A patient has melanoma that has spread to her brain, lungs, and spleen. What complications may...
A patient has melanoma that has spread to her brain, lungs, and spleen. What complications may be expected with this diagnosis? Is treatment available and effective? Life expectancy?
4. Is it possible for a patient to become infected with HPV and later eliminate the...
4. Is it possible for a patient to become infected with HPV and later eliminate the infection without any medical intervention? Explain your answer. .5. Can HPV transmission occur in the absence of sexual intercourse? Do condoms offer full protection against HPV infection? 6. Approximately how many types of HPV exist? How many types are included in the current HPV vaccine?
If a patient was HIV-1 infected and in the early years of the asymptomatic phase, would...
If a patient was HIV-1 infected and in the early years of the asymptomatic phase, would the viral load in the blood vary significantly? What about CD4+ T cell counts, etc? This would be assuming no drug treatment.
1. A cystic fibrosis patient with normal coloration of the mucus is infected with a bacteria...
1. A cystic fibrosis patient with normal coloration of the mucus is infected with a bacteria able to metabolize a variety of organic chemicals. What is this nosocomial pathogen common among cystic fibrosis patients? Haemophilus influenzae Burkholderia Pseudomonas aeruginosa Klebsiella pneumoniae Coxiella burnetii
Salmonella entericaTyphi is located in the ______________ of chronically infected carriers. Colon Large intestine Small intestine...
Salmonella entericaTyphi is located in the ______________ of chronically infected carriers. Colon Large intestine Small intestine Gallbladder Which strain of E. coliis the cause of “traveler’s diarrhea?” Enterophatogenic (EPEC) Enterotoxigenic (ETEC) Enterohemorrhagic (EHEC) Enteroaggregtive (EAEC) Listeria monocytogenesinfection of pregnant women can result in? Miscarriage Stillbirth Premature labor All of the above The most common source of botulism is… undercooked meat, poultry, or fish ready-to-eat meat and unpasteurized dairy undercooked eggs improperly home-canned goods TRUE or FALSE: Norovirus can be shed...
COLLAPSE You receive an specimen in the lab from a patient with an infected throat. Chronicle...
COLLAPSE You receive an specimen in the lab from a patient with an infected throat. Chronicle the steps you would take to identify the bacteria present, starting with what stains, culture media, selective and differential. you would use and why?
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT