What is meant by oxygen saturation? Can we achieve 100% oxygen
saturation of hemoglobin without a...
What is meant by oxygen saturation? Can we achieve 100% oxygen
saturation of hemoglobin without a hyperbaric chamber?
Solutions
Expert Solution
Oxygen saturation refers to the maximum amount of oxygen that
can be transported by the 100 mL of blood. In normal condition of
20 mL of oxygen by 100 mL of blood.
The oxygen can be occurred either as diffusion or bind with
plasma protein or bind with Hb. The binding with Hb is indicated by
the oxygen saturation curve.
The saturation of blood depends on the partial pressure of the
individual gases.
The saturation can reach 100% at a pressure above 17kPa or 128
mmHg that is with an increase in the partial pressure of the oxygen
saturation also increases. No further increase in saturation can be
obtained with increase partial pressure further.
Also, an increase in breathing at an area which is having a
higher concentration of oxygen will increase the partial pressure
of oxygen thus there will be an increase in oxygen saturation.
The hyperbaric chamber uses the principle of increasing the
oxygen dissolving rate into plasma by increasing atmospheric
pressure.
Thus higher atmospheric pressure required for increasing
saturation. At a higher altitude with higher atmosphere pressure
100% saturation can be acquired.
Draw an oxygen saturation curve for hemoglobin (pressure of O2
versus saturation (y)) with physiological levels of CO2 and 2,3-BPG
at biological pH. Now using arrows to indicate which direction it
moves, draw the shift in this curve when:
a) There is a decrease in CO2
b) There is an increase in 2,3-BPG
c) There is an increase in pH
d) Hemoglobin experiences a loss of quaternary structure (breaks
up into monomers)
If you plot an oxygen-hemoglobin saturation curve for a mammal
and want to add a curve for myoglobin, you would have to put place
it _________ the o2-Hb curve. This reflects myoglobin's affinity
for oxygen.
A. over; similiar B. to the left of; increased C. To the right
of; decreased D. to the right of; increased
In mammals, the major control of ventilation is blood_______and
in fish, the major control of ventilation is blood________.
A. Co2 level; oxygen level B....
1) What is meant by the principle of connectivity in
research?
2) How can we achieve convergence in science?
3)What is a meta-analysis?
4) What do we mean when we say there is no "magic bullet" in
explaining a phenomenon or behavior?
Given knowledge of local regulation of gas transport, the
oxygen-hemoglobin saturation curve, and neural control of
respiration, give at least five reasons why exercising muscles that
use more oxygen and produce more carbon dioxide, lactic acid and
heat would have more oxygen delivered to them.
Topic 9: Oxygen-hemoglobin dissociation
curve
Define what the oxygen hemoglobin dissociation curve is
and describe why it is physiologically important. explain the
significance of the sigmoidal shape, including the physiological
significance of the plateau and step portions, and the relationship
between oxygen loading/unloading with changes to po2
Give an example of a situation/condition that would
result in a right shift of the oxygen hemoglobin dissociation
curve. explain what causes the shift and relate it to oxygen
binding affinity, loading-unloading of...
1. What is the approximate hemoglobin O2 saturation of a blood
sample that contains 10 g Hb/100 ml blood and has an O2 content of
10 ml O2/100 ml blood (ignore physically dissolved O2)? Show
work
2. About 40% of Ca2+ in the blood is bound to plasma proteins,
such as albumin. The [Ca2+] in Bowman’s Capsule is ~ 3 mEq/l,
whereas its concentration in the plasma is ~ 5 mEq/l. Why the
difference in [Ca2+] between these two compartments?...
Adult hemoglobin (iron-containing protein) can carry up to four
oxygen molecules per hemoglobin molecule, with the addition of
oxygen proceeding in a step-wise fashion. For the third step, the
value of the equilibrium constant is Keq=5.86 x 10^-4 although the
reaction has a (delta Hº) value of -2.9 kj/mol (Remember that the
system is not at room temperature).
Heme-Fe^2+ -(O2)2 + O2 <----> Heme-Fe^2+ -(O2)3
Keq=5.86 x 10^-4
(a) calculate delta Gº for this process.
(b)From the information provided, calculate...
What other factors will promote oxygen release from hemoglobin?
What factors promote binding of oxygen to hemoglobin?
High levels of CO2 will promote oxygen
release/binding (Pick one). Explain in terms of
metabolic pathways why high levels of CO2 would promote
release/binding of oxygen
How does the protein sequence of hemoglobin differ from normal
hemoglobin? How does this change affect the structure of the
protein? Explain what happens on the protein level to cause the
sickling of the Red blood cells.