What happens in lymphopoiesis in embryonic and adult stages of development. Alongside the key steps in...

What happens in lymphopoiesis in embryonic and adult stages of development. Alongside the key steps in each stage, also mention some influencing factors relating to its development

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Expert Solution

Lymphopoiesis :Lymphopoiesis refers to the process by which the cellular components of the immune system (i.e., T cells, B cells, and natural killer cells, and certain dendritic cells) are produced during hematopoietic differentiation. This process begins with the hematopoietic stem cell and continues through progenitor stages down a series of mostly diverging lineage pathways, ultimately resulting in the remarkable diversity and flexibility of the immune system

Stages :

.pHSC pluripotent, self-renewing, hematopoietic stem cells which give rise to.

.MPP multipotent progenitors, which give rise to.

.ELP (or PRO) Prolymphocytes, early lymphoid progenitors, and finally to the.

.CLP Common lymphoid progenitor, a cell type fully committed to the lymphoid lineage.

The CLP is the transit cell responsible for these (generally parallel) stages of development, below:

.NK cells

.Dendritic cell

.Progenitor B cells

.Pro-B cells => Early Pro (or pre-pre)-B cells => Late Pro (or pre-pre)-B cells

.Large Pre-B cells => Small Pre-B cells

.Immature B cell

.Plasma cell and b cell

Sydney Mullin answered 9 months ago

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