Question

What are coagulant drugs ?

Answer 1

COAGULANT DRUGS :-

Definition :-

Coagulants are the agents which promotes coagulation .

They are indicated in hemorrhagic states .

Coagulant drugs :-

1. Vitamin K :-

Vitamin K exists in 3 different forms :

● Vitamin K₁ :- (derived from plants)

- Phylloquinone

● Vitamin K₂ :-

- Menaquinone

● Vitamin K₃  :- (synthetic)

i. Fat soluble :-

- Menadione

- Acetomenaphthone

ii. Water soluble :-

- Menadione sodium bisulfate

- Menadione sodium diphosphate

Action :-

- Vitamin K acts as cofactor for synthesis of clotting factors , mainly factors II , VII , IX and X

- It participate in carboxylation of the glutamic acid residue of prothrombin .

​​​​​​- It is also involved in electron transport (coenzyme ) and oxidative phosphorylation .

Therapeutic uses :-

◆ In the adults , vitamin K deficiency due to malabsorption , prolonged malnutrition , jaundice

◆ Vit . K deficiency in infant due to diarrhoea

◆ Neonatal vit. K deficiency

◆ Overdose of oral anticoagulants or bleeding state during oral anticoagulants therapy.

2. Miscellaneous drugs :-

● Human fibrinogen

● Antihemophilic factor

● Desmopressin

● Adrenochrome monosemicarbazone

● Rutin

● Ethamsylate