Question

1.

Suppose a researcher is interested in carrying out a phase II clinical trial in order to assess the effectiveness of four different doses of an investigational new drug. Assume the following table represents the summary statistics revolving around the number of adverse events in the four fasting glucoses among the groups.

Fasting Glucose	Treatment Group
124	1
124	1
125	2
134	2
138	2
137	2
136	2
119	1
124	3
120	1
116	3
124	3
127	3
129	1

A) Calculate the MSW.

B) Calculate the MSB

a		A) MSW=154.741 B) MSB=31.226
b		A) MSW=186.198 B) MSB=29.714
c		A) MSW=194.689 B) MSB=21.777

2.

A researcher is interested in the effectiveness of a new asthma medication at increasing the forced vital capacity (FVC) in children. The medicated spray to be used via inhaler has moved into phase II of clinical trials where five different treatment doses are being tested against the control best standard of care. Suppose the following incomplete ANOVA table summarizes the preliminary analysis for the study.

	Sum of Squares	df	Mean Square
Between Groups	4032.2
Within Groups		439
Total	7492.7

A) Complete the ANOVA table

B) Calculate an F statistic and a pvalue.

a		A) SSW=3469.5, dfB=5, dfT=444, MSB=806.44, MSW=7.90 B) F=102.1, pvalue ~0
b		A) SSW=2561.2, dfB=10, dfT=125, MSB=502.14, MSW=11.2 B) F=123.8, pvalue ~1
c		A) SSW=1259.0, dfB=15, dfT=236, MSB=678.24, MSW=9.11 B) F=99.5, pvalue ~0

Answer 1

Question 1.

Using Minitab:

• Click Stat → ANOVA → One-way.
• A new window named “One-Way Analysis of Variance” pops up.
• Select “'Fasting Glucose'” as “Response.”
• Select “'Treatment Group'” as “Factor.”

• Click “OK.”
• The ANOVA results appear in the session window.

Correct Optiob C.

A) MSW=194.689 i

B) MSB=21.777

Hope this will be helpful. Thanks and God Bless You.