what is the role of the kidney and bone marrow in this increase of RBCs?

Expert Solution

RBCs(erythrocytes) are produced in the red bone marrow present in the ends of long bones and in flat and irregular bones.

Development of erythrocytes includes several stages :-

Pleuripotent stem cells - - - > proerythroblasts - - - >erythroblasts - - - >. reticulocytes - - - > mature RBCs.

Pleuripotent stem cells to reticulocytes are formed in bone marrow. Reticulocytes are then released to blood and mature RBCs are formed with the help of vitamin B12 and folic acid.

Bone marrow produces erythrocytes at the rate which they are destroyed.

**But when hypoxia occurs(decreased oxygen supply to tissues),kidneys produce a hormone called erythropoietin. Erythropoietin stimulates an increase in the production of proerythroblasts and thus increased number of reticulocytes are released into the blood. When number of reticulocytes increased, RBC s will also get increased. More RBCs will increase the oxygen carrying capcity of blood and hypoxia is reversed - - - >leads to decreased production of erythropoietin.

Sydney Mullin answered 1 year ago

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