Question

1. Nicotinic acetylcholine receptors exist in several forms. Which one is more associated with controlling cardiac output?

a. The CNS type on post synaptic membranes

b. The muscle type on pre-synaptic membranes

c. The ganglion type that increases Ca++ currents

d. The ganglion type that increases Na+/K+ currents

e. The M2 type on cardiac cells

2. Neurotransmitter receptors in the autonomic nervous system are all G-protein coupled receptors, except for one. Which one?

a. Nicotinic acetylcholine receptors

b. Muscarinic acetylcholine receptors

c. Alpha adrenergic receptors

d. Beta1 adrenergic receptors

e. Beta2 adrenergic receptors

3. In the heart, muscarinic acetylcholine receptors can slow heart rate by manipulating a second messenger system. The same second messenger is manipulated by another autonomic neurotransmitter receptor to speed heart rate. What is the second messenger and the stimulatory receptor?

Norepinephrin and nicotinic receptors

cAMP and beta adrenergic receptors

IP3 and alpha adrenergic receptors

DAG and beta adrenergic receptors

cAMP and alpha adrenergic receptors

4. Eating certain mushrooms can lead to constricted pupils, diarrhea, vomiting, hallucinations, and sweating, among other signs of poisoning. Agonism of which one of the following receptors is most often associated with these signs?

Niconitin acetylcholine receptor

Muscarinic acetylcholine receptor

Alpha1 adrenergic receptor

Beta1 adrenergic receptor

Beta2 adrenergic receptor

5. When activated, certain receptors can cause vascular smooth muscle contraction leading to blood vessel constriction. This results in increased vascular resistance and blood pressure. Downstream of the receptor, a second messenger is responsible for more directly triggering vascular smooth muscle contraction. Which one of the following pairs of receptor and signaling molecule is most directly responsible for driving vascular smooth muscle contraction and increased blood pressure?

Nicotinic receptors and Na+

Muscarinic receptors and cAMP

Alpha1 adrenergic receptors and Ca++

Alpha2 receptors and K+

Beta1 receptors and cAMP

6. Increased Ca++ concentrations in cardiomyocytes during the contraction phase of the cardiac cycle is driven by activation of which one of the following receptors and the associated second messenger?

Alpha1 adrenergic receptors and cAMP

Beta1 adrenergic receptors and cAMP

Beta2 adrenergic receptors and IP3

Nicotinic acetylcholine receptors and DAG

Muscarinic acetylcholine receptors and Ca++

7. Sympathetic stimulation of juxtaglomerular cells is mediated via...

Alpha1 cholinergic receptors

Muscarinic adrenergic receptors

Nicotinic acetylcholine receptors

Beta1 adrenergic receptors

Angiotensin II receptors

8. Benzedrine is a drug containing the racemic mixture of amphetamine, which is an equal parts mixture of levoamphetamine and dextroamphetamine. It was first marketed in 1933 as a decongestant in the United States in the form of inhalers. It was subsequently used for a wide variety of medical and military applications such as for weight loss or to prevent drowsiness. Benzedrine tablets gained considerable popularity as a recreational drug, being known colloquially as cross-tops or Bennies, to the degree that the drug is now listed as a controlled substance. Benzidrine has been immortalized in song by numerous artists including Elton John (Bennie and the Jets) and Tom Lehrer (Bright College Days). Benzedrine is an example of a...

Non-selective adrenomimetic agent

Non-selective cholinomimetic agent

Non-selective adrenolytic agent

Non-selective cholinomimetic agent

Muscarinic agonist

9. For thousands of years, human consumption of fungus (Claviceps purpurea)-contaminated rye grains has led to adverse effects. The symptoms are generally referred to as St. Anthony's Fire because of a group of European monks (the Hospital Brothers of St. Anthony) who became renowned for their attempts to alleviate the suffering of the afflicted. Ergot alkaloids produced by the fungus (e.g., ergotamine) are responsible for ergotism, a form of poisoning that results from sufficient exposure and includes signs/symptoms including burning of the limbs with consequent gangrene in some cases, hallucinations and attendant irrational behavior, convulsions, strong uterine contractions, nausea, seizures, high fever, vomiting, loss of muscle strength, unconsciousness, and even death. Ergot alkaloids have been employed for centuries as abortifacients. Agents of this type are classified as...

Non-selective adrenomimetics

Non-selective cholinomimetics

Beta adrenergic agonists

Alpha adrenergic agonists

Nicotinic antagonists

10. Propranolol is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is used to treat high blood pressure (although better drugs have since been developed for this), irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, essential tremors, and to prevent migraine headaches, among other ailments. Use of propranolol is also associated with a variety of common side effects. Propranolol was discovered in 1964 by British scientist James W. Black, a success for which he was later awarded the Nobel Prize. In a 1987 study by the International Conference of Symphony and Opera Musicians, 27% of interviewed members admitted to using propranolol or similar agents for musical performances. For about 10–16% of performers, their degree of stage fright is considered pathological. Propranolol is categorized as a...

Non-selective cholinomimetic agent

Nicotinic antagonist

Beta adrenergic antagonist

Beta-1 adrenergic antagonist

M2 muscarinic agonist

Answer 1

1. M2 type of cardiac cell is associated with controlling cardiac output. because M2 receptor is present in heart.

explanation:

CNS type postsynaptic membrane are present in brain and responsible for post and presynaptic action.

muscle type presynaptic membrane are present at neuromuscular junction and responsible for EPSP effect.

ganglion type nicotinic receptor present in autonomic ganglia are responsible for EPSP effect by increasing na+ and k+ permeability.

2.Neurotransmittrer receptors in ANS are all G-Protein coupled recepto.because except

a. nicotinic acetylcholine receptors. because:

nicotinic receptor is ligand gated ion channel receptors. Nicotinic ACh receptors (nAChRs) open to allow flux of Na(+), Ca(2+), and K(+) ions into the cell after activation.

others are G protein-coupled receptor (GPCR),and also called seven-transmembrane receptor or heptahelical receptor, protein located in the cell membrane that binds extracellular substances and transmits signals from these substances to an intracellular molecule called a G protein (guanine nucleotide-binding protein)