Question

There are often several receptor subtypes for one neurotransmitter, like acetylcholine, which are distributed in different parts of the nervous system. Why might it be useful to have different receptor subtypes in specific areas? What clinical implications would it have?

Answer 1

acetylcholine is received by chapters and then information is proceeded for signaling process.

there are two type of acetylcholine receptors muscarinic acetylcholine receptors and nicotinic acetylcholine receptors.

muscarinic acetylcholine receptors are G protein coupled receptors and the transmit the information and signals very slowly because they involve Cascade of secondary messengers.

nicotinic receptors are all I can get it protein channels the involved high speed of transmission of neurotransmitter from one path to desired path.

muscarinic receptors are involved in the activity of heart rate generation, smooth muscle contraction and release of neurotransmitter. muscarinic receptors are divided into 5 subtypes on the basis of their pharmacological activities.

M1 M2 M3 M4 M5

M1 muscarinic acetylcholine receptors for for secretory glands.

M2 muscarinic acetylcholine receptors are for cardiac tissues.

M3 muscarinic acetylcholine receptors are for smooth muscles and security gland.

M4 inhibits adenylyl cyclase enzyme at the time of signalling process.

M5 involved in the generation of secondary messengers like Ip3 DAG.

nicotinic acetylcholine receptors are present at the region of neuromuscular Junction and involved in the contraction of muscle and relaxation of muscles.

the transmits the neurotransmitters for muscle contraction and contraction control.