Question

In: Chemistry

As hemoglobin is formed in the body, how does the heme coenzyme associate with this protein?...

As hemoglobin is formed in the body, how does the heme coenzyme associate with this protein?

A. Hydrogen Bonds

B. They are covalently attached to the protein

C. They are a modified "R" group of a non-standard amino acid

D. Hydrophobic force

E. Coordination of the iron atom with the distal histidine residue

Solutions

Expert Solution

Ans. Correct options- A, C, D

Option A. Correct: The O- and H-atoms of –COOH group in ring C and D of the heme group may form H-bonds with adjacent residues.

Option. B. Incorrect. The heme group is NOT linked to protein with any covalent bond.

Option. C. Incorrect. Heme group is a substituted tetrapyrrole, but NOT modified R group of any amino acid residue.

Option. D. Correct. Hydrophobic force: The bulk of heme is hydrophobic with which it exerts hydrophobic interactions with adjacent hydrophobic regions in the groove of protein. Thus interaction also is crucial for positioning the heme group in protein’s hydrophobic pocket.

Option E. Correct. Coordination of the iron atom with distal histidine residues.

Heme B (heme present in Hb and Myb) prosthetic group consists of four pyrrole groups (tetrapyrrole) connected by acetylene group between adjacent rings. A Fe2+ is held at the center of tetrapyrrole with five coordination bonds- four coordination bonds (one between the Fe2+ ion and N-atom of each rings) with the ring, and one below the plane between Fe2+ ion and an imidazole N-atom of histidine residue of the subunit.

Note: All the three types of interactions (H-bond, coordination bond, and hydrophobic interactions) are crucial for correctly positioning the heme prosthetic group in hemoglobin monomer. Any single interaction would NOT be sufficient enough to the stable interaction between heme and protein.


Related Solutions

What are the R and T forms of hemoglobin how does the heme structure differ in...
What are the R and T forms of hemoglobin how does the heme structure differ in each? What forces stablize the T state?
Protein Molecular Weight Isoelectric point Does the protein contain heme moiety? 1 68,000 5.5 No 2...
Protein Molecular Weight Isoelectric point Does the protein contain heme moiety? 1 68,000 5.5 No 2 15,000 5.0 No 3 17,500 9.5 Yes Could gel filtration chromatography be used to separate a mixture containing proteins 1 & 3? If gel filtration chromatography can be used, which protein would elute las? After collection fractions from the column, the absorbance of each fraction will be measured in a spectrophotometer - can both proteins 1 & 3 be monitored at 280 nm and...
Recognize the structure of the heme group and know its purpose in hemoglobin or myoglobin
Recognize the structure of the heme group and know its purpose in hemoglobin or myoglobin
WHAT DOES THE ENCODED PROTEIN DO IN THE BODY?
WHAT DOES THE ENCODED PROTEIN DO IN THE BODY?
why is hemoglobin a globular protein
why is hemoglobin a globular protein
Which enzyme contains the coenzyme biotin? What is the function of this coenzyme and how is...
Which enzyme contains the coenzyme biotin? What is the function of this coenzyme and how is it covalently attached to the enzyme? Show the steps in the mechanism of this enzyme.
1. a. What are the important amino acids around heme in myoglobin/hemoglobin. b. Why is Fe...
1. a. What are the important amino acids around heme in myoglobin/hemoglobin. b. Why is Fe a +2 charge in the protein environment but able to oxidize to fe 3+ in a non-protein environment? Why is this pertinent to Oxygen binding?
Which of the following statements about hemoglobin is false? a. hemoglobin is a very large protein...
Which of the following statements about hemoglobin is false? a. hemoglobin is a very large protein composed of four large protein subunits b. there are two alpha (α) and two beta (β) subunits in each hemoglobin molecule c. each alpha and beta subunit includes a heme group d. oxygen (O2) molecules bind irreversibly to an iron ion (Fe++) in a heme group Which of the following statements about oxygen delivery to the body tissues is false? a. low oxygen concentration...
Explain how hemoglobin is catabolized by the body in both extravascular and intravascular hemolysis. Explain the...
Explain how hemoglobin is catabolized by the body in both extravascular and intravascular hemolysis. Explain the effect of the following on RBC survival. Explain your answer. Explain how EPO regulates RBC production.
please discuss what are the roles/ use/ metabolism of protein in the body? How were protein...
please discuss what are the roles/ use/ metabolism of protein in the body? How were protein requirements established for healthy adult individuals and athletes (consider if they overconsume)? Why was there no change in the RDA for protein? Discuss the risks associated with over-consumption of protein and under-consumption of protein
ADVERTISEMENT
ADVERTISEMENT
ADVERTISEMENT