why is hemoglobin a globular protein

Expert Solution

Hemoglobin is a conjugated protein (molecular weight 67,000 Daltons) composed of the protein globin and a prosthetic group known as heme. Each hemoglobin molecule contains four subunits held together by non covalent forces. is subunit consists of a molecule attached to a polypeptide. the four polypeptides (2 alpha and 2 beta) of a hemoglobin molecule are collectively called globin. Each Alpha globin chain has 141 amino acids and beta globin chains have 146 amino acids each. When a protein contains more than one polypeptide chain, it is called a quaternary protein. It is also called as globular proteins. Examples of other globular proteins: enzymes, myoglobin.

Globular proteins form a sphere. The hydrophobic ends go inside the sphere whereas the hydrophilic polymer ends get arranged at the outer surface of the sphere. This makes the globular proteins water soluble. As the human body mostly contains water, all the reactions that occur in human body have to occur in aqueous medium therefore the major proteins like enzymes, hemoglobin have to be water soluble. Hence hemoglobin is a globular protein. Hemoglobin is present in the cytoplasm of RBCs which float in the blood. Hence it is present in aqueous medium.

Structure of tetrameric Hemoglobin and structure of heme::

gladiator answered 2 years ago

Describe the likely order of events for the folding of a globular protein and why is...

Describe the likely order of events for the folding of a globular protein and why is this sequence of events likely? What is the chemical/physical rationale for each step? Include a brief discussion of Levinthal’s paradox.

is keratin fibrous or globular? why?

. Protein X is a single polypeptide with three functional domains. The first is a globular...

. Protein X is a single polypeptide with three functional domains. The first is a globular domain which has a protein binding domain and contains both alpha-helices and beta-sheets. The second domain is a group of seven alpha-helices that contain mostly hydrophobic amino acids. The third domain appears to be an enzymatic domain which transfers a phosphate group from ATP to a hydroxyl group on another protein. Postulate the function of this protein and give reasons that support this prediction.

Which of the following statements about hemoglobin is false? a. hemoglobin is a very large protein...

Which of the following statements about hemoglobin is false? a. hemoglobin is a very large protein composed of four large protein subunits b. there are two alpha (α) and two beta (β) subunits in each hemoglobin molecule c. each alpha and beta subunit includes a heme group d. oxygen (O2) molecules bind irreversibly to an iron ion (Fe++) in a heme group Which of the following statements about oxygen delivery to the body tissues is false? a. low oxygen concentration...

What would be the expected orientation of an amphipathic alpha helix occurring in a globular protein...

What would be the expected orientation of an amphipathic alpha helix occurring in a globular protein in aqueous solution? Select one: a. Hydrophilic amino acids are complementary to hydrophobic amino acids, so the hydrophilic side of the alpha helix should be facing toward the hydrophobic core of the protein. b. A soluble protein will have mostly hydrophilic amino acids in its core, so the helix will be arranged to have the hydrophilic side facing toward the core of the protein....

You are a researcher in a biochemistry lab which investigates a novel, globular protein production by...

You are a researcher in a biochemistry lab which investigates a novel, globular protein production by yeast. The director of the lab asks you to produce and purify the protein. Unfortunately, you could not obtain any information about if the protein is extracellular or intracellular. Within this scope, please propose a method/methods for isolating the protein after the production process. You have a well-equipped laboratory with the equipment would require to isolate and purify. In addition describe an experiment or...

Biochemistry Can someone explain what the purification process is for the globular protein insulin? And clarify...

Biochemistry Can someone explain what the purification process is for the globular protein insulin? And clarify its function & importance.

Find the human hemoglobin subunit alpha protein on PDB (Protein Data Bank) protein database. Hint: You...

Find the human hemoglobin subunit alpha protein on PDB (Protein Data Bank) protein database. Hint: You can use also use PDB identifier “5HU6” to find human hemoglobin subunit alpha protein on PDB database. (a) Find the Experimental Data section on this protein page and report Method and Resolution used? (b) Find the Entry History section on this protein page and report Deposited Date and Deposition author(s)? (c) Find the secondary structure information for this protein structure. What secondary structure types...

In humans a normal allele for one of the polypeptide chains of the protein hemoglobin is...

In humans a normal allele for one of the polypeptide chains of the protein hemoglobin is incompletely dominant to the allele for an abnormal polypeptide chain. Individuals with two abnormal alleles have the disease sickle cell anemia; they only make irregular polypeptide chains. Heterozygotes are called carriers or people with the trait. Their hemoglobin contains both the normal polypeptide and the irregular one. Problem: Two of your friends want to marry and have children. They both are carriers for Sickle...

Adult hemoglobin (iron-containing protein) can carry up to four oxygen molecules per hemoglobin molecule, with the...

Adult hemoglobin (iron-containing protein) can carry up to four oxygen molecules per hemoglobin molecule, with the addition of oxygen proceeding in a step-wise fashion. For the third step, the value of the equilibrium constant is Keq=5.86 x 10^-4 although the reaction has a (delta Hº) value of -2.9 kj/mol (Remember that the system is not at room temperature). Heme-Fe^2+ -(O2)2 + O2 <----> Heme-Fe^2+ -(O2)3 Keq=5.86 x 10^-4 (a) calculate delta Gº for this process. (b)From the information provided, calculate...

Question