Skeletal muscle: aspects of substrate utilization by activity, muscle type, activation

Expert Solution

Tthe main substrate utilized by the Skeletal muscles are Carbohydrate like glucose, Fattyacid from the lipid, Lactic acid.

The substrate utilization by the skeltal muscle will depend upon the condition.

If there is enough oxygen supply to the skeletal muscle, it will utilize the glucose for ATP production by means of cellular Respiraton.

If there is no glucose available, the body will depend Mainly on the Fats.

Fat are digested into Fattyacid and Glycerol.

Fatty acid are further oxidised to Acetyl coA by Beta oxidation ,Acetyl coA enters the krebs cycle for ATP, NADH,FADH2 production.

NADH,FADH2 are further trasnported to Electron transport chain for producing ATP.

When skeletal muscle is defficient of Oxygen supply , Pyruvic acid formed as a part of Glycolysis will enter the Lactic acid fermentation reaction in which pyruvic acid is converted into lactic acid . it will produce NAD+ which are utilised for the Glycolysis and ATP are generated.

2)Skeletal muscle is a striated muscle.

Long cylindrical muscle

multinucleated cell

Volundary muscle innervated by the somatic nervous system.

function : Movement of the body

3) when a motor nerve innervate the the muscle fibre(myofibrils) , pre synaptic nerve endings releases acetylcholine neurotransmitter into the synapse -------> it bind with the postsynaptic receptor on the muscle membrane -------> depolarises the sarcolemma(muscle membrane) ------->depolarisation of the T tubules -------->Calcium ion are released by the sarcoplasmic reticulum into the sarcoplasm------> it bind with the Troponin c present on the tropomyosin - actin complex------> change in spatial configuration of the tropomyosin result in the exposure of actin binding site -------> Myosin filament bind with the exposed actin binding site ----> Actin filament(thin) slide over the myosin(thick) filament ----> muscle contract.

Sydney Mullin answered 1 year ago

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