Does histone modification involve methylation? If so, how so?

Expert Solution

Answer- Yes, histone modification involve methylation.

It is a type of covalent modification in histones and it is considered a part in epigenetics in eukaryotic cells.
In histone methylation, basic amino acids lysine (K) & arginine (R) of histone tails are methylated.
Enzymes involved - histone methyltransferases (HMT) , histone demethylases (HMD).

Examples of HMT (Histone Methyl Transferases)-

Dot1 class lysine methyltransferases
SET domain containing lysine methyltransferases

Examples of HDM (Histone Demethylases)-

LSD1 (lysine -specific demethylases)
PADI4( petidyl arginine deiminase 4)

How histone methylation is occuring is described in the photos attached. Other important points are also provided in the photos attached.

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