Question

Which of the following is an accurate statement regarding the difference between lipid-soluble and water-soluble hormones?

a.Lipid-soluble hormones do not directly activate genes; water-soluble hormones directly activate genes.

b.Lipid-soluble hormones cannot pass through cell membranes; in general, water-soluble hormones can.

c.Lipid-soluble hormones are made from amino acids whereas water-soluble hormones are not.

d.Lipid-soluble hormones attach to receptors in the cytoplasm; water-soluble hormones attach to membrane-enclosed receptors.

Answer 1

Answer D. Lipid solube hormones attach to receptors in cytoplasm; water soluble hormones attach to membrane-enclosed receptors

Explanation:

Examples for Lipid soluble hormones are steroid hormones like Aldesterone, 11 Deoxycorticosterone, Cortisol, Corticosterone, Testosterone, Dihydrotestosterone, Dihydroepiandrosterone, Androstenedione, Estrogen, Progesterone

Lipid soluble hormones(Steroid hormones)-mechanism of action:

Lipid soluble hormones(Steroid hormones)

Cytoplasmic receptors

DNA

mRNA

Protein synthesis

As we can see from the above table, lipid soluble hormones act by attaching to cytoplasmic receptors to mediate their action

Water souble hormones-mechanism of action:

Examples for water soluble hormones are Protein hormones like Growth hormone, Thyroid stimulating hormone, Adrenocorticotropic hormone, Follicle stimulating hormone, Leutinizing hormone, Prolactin, Antidiuretic hormone, Oxytocin, parathormone, Calcitonin, Insulin, Glucagon, Somatostatin, Pancreatic polypeptide, Human chorionic gonadotropin, Human chorionic somatomammotropin.

Water soluble hormones

Membrane enclosed receptors

Second messenger like Cyclic AMP

Enzyme activation

As we can see from the above description, water soluble hormones attach to the membrane enclosed receptors

Hence, Option D is the correct answer