Question

Does aging affect the immunological advantages of regular exercise. If so, how and why ?

Answer 1

Again is generally associated with immunisenscence or dysregulation of immune system. It impacts both innate and adaptive immunity, leading to increased incidence of infectious diseases, autoimmunity, cancer, inflammatory conditions etc.

Excercise simply counteracts the immunosenescence. Long term and moderate physical activity is associated with reduction in incidence of infectious diseases.

There is  increased rates of vaccine efficacy and improvement in physical and physiological living.

Excercise impacts the T -cell proliferation, production of cytokines and production of antibodies in response to vaccine.

Excercise reverses the effects of old age on immunity by increasing the production of endocrinal hormones which contribute to less accumulation of autoreactive by enhancing the programmed cell death.

Excercise is associated with release of hormones called endorphins which are immune system strengtheners. Immune cells have endorphin receptors and rely on endorphins to function properly. They stimulate immune system by activating white blood cells which protects against disease infection.