5) An inbred mouse of MHC haplotype b (MHCb) receives a bone marrow transplant from an...

5) An inbred mouse of MHC haplotype b (MHCb) receives a bone marrow transplant from an F1 mouse (MHCaxb) that results from a cross between an MHCa and an MHCb mouse. What will happen?

a. The mouse will have no CD4+ T cells (no T helper cells)

b. The mouse will have severe autoimmune disorders

c. The mouse will have mature T cells with TCRs mostly restricted to recognizing the antigen they are specific for on MHCb proteins.

d. The mouse will have mature T cells with TCRs that can recognize the antigen they are specific for on MHCa or MHCb proteins.

Expert Solution

Option B is correct answer

Mouse will have severe autoimmune disorder.

Explanation

MHC alleles found on a single chromosome form a particular combination known as an MHC haplotype. MHC alleles is codominant pattern of expression. Both the allels present at a locus exressed both the protein the cell. Both gene products present antigen to T cell. Here MHC ab haplotype bone marrow is transplanted in to MAC b haplotype. So this MHC ab haplotype has both the proteins of a and B on the cell surface and will be recognized as non self. Which lead to generation of autoimmune response against the transplanted bone marrow cell.

gladiator answered 2 years ago

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