1. Two distinct lineages of T cells can be identified based on their expression of a:b...

1. Two distinct lineages of T cells can be identified based on their expression of a:b versus g:d T-cell receptors. A deficiency in the signaling receptor Notch1 would result in:

Group of answer choices

a. A loss of a:b but not g:d T cells

b. A loss of both of a:b and g:d T cells

c. A loss of a:b T cells and a massive expansion of g:d T cells

d. An increased number of both of a:b and g:d T cells

e. A normal number of both of a:b and g:d T cells

2. Unlike a:b T cells, g:d T cells are considered to be components of the innate immune system. All of the following features of g:d T cells that lead to their classification as innate cells except:

Group of answer choices

a. They migrate from the thymus directly to barrier surfaces such as mucosa and epithelia

b. Their ability to produce effector cytokines within hours of initial activation.

c. Display a homogeneous expression of a single specific Vg and Vd in their T-cell receptors

d. That their T-cell receptors are germline encoded rather than a product of VD-J recombination

Expert Solution

1) Notch signalling helps in the control of cell fate prolifIration, differnciation. Notch is helpful for T-cell lineage differenciation including T cells. so loss of function of Notch receptors involving in the bloks the development of T-cell development and accumulation of immature B-cells in thymus So when a signalling receptor is about loss of function it leads to loss of both a:b and g:d T cells . notch generally bind to delta receptors in immunology mainly Tcell development.

2) T cells act as a bridge between innate and adaptive immune system so according to the given question the first option include innate immune system innate imune is first immune system is not specific in nature maximum T cells will not included in innate immune system the mucosa and epithilia mainly include in innate system.

second option include activation of effector cytokines within hours also include innate immune system and adaptive immune system is always dependent and long term process takes more than 96 hours for its activation so seond option is not included.

Tcell expressing a heterodimeric gd tcell receptor and they incesed frequency in mucosal tissues and skin. ab T cellls express a TCR that is generated from a germline pool of variable va and vd genes are avialable in the germline genome to construct a functional gd TCR in the immune system.

gladiator answered 2 years ago

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