Question

For Amphetamines, opiates, barbiturates, and chloropromizine answer the following for each:

- Type of receptor it binds to. Ion channel recept or GPCRs, is it excitatory or inhibitory on postsynaptic cell.

- Identify the endogenous molecule that the drug is interacting with and how it changes its function.

-Discuss the changing synaptic transmission by drugs based on the neural circuits that are affected.

Answer 1

OPIODS

Type of receptors:opiod receptors.There are mainly three type of receptors of opiods they are mu, delta and kappa receptors.They are G-protein coupled receptors

Effect on postsynaptic cell:Either excitatory or inhibitory

Drug interactions:Alcohol and antiseizure medications like carbamazepine metabolism is enhanced by increase in hepatic microsomal enzymes.

Effect on synaptic transmission:It causes analgesic effect through mu receptors at spinal and supraspinal sites.

CHLORPROMAZINE

Type of receptors: dopamine receptor.ligand gated ion channels

Effect on postsynaptic cell: inhibitory to postsynaptic cell

Drug interactions:the drugs which increase dopamine in body interacts with the chlorpromazine

Effect on synaptic transmission:It is a antipsychotic.It blocks D2 receptors.

AMPHETAMINES

Type of receptors:alpha and beta receptors which are G-protein coupled receptors

Effect on postsynaptic cell: excitatory effect

Drug interactions:interacts with MAO inhibitors and increase in the metabolism of amphetamines.

Effect on synaptic transmission:It is used in attention deficient hypersensitivity disorder as it activates alpha and beta receptors