Question

1. The NKCC2 transporter is blocked by ____ as a treatment ____

   1. Loop diuretics ; to reduce Na+ reabsorption

   2. ACE inhibitors; to reduce fluid excretion XX

   3. Thiazides; to reduce fluid retention

   4. K sparing diuretics; for hypertension

2. Which of the following would be a result of treatment with an ACE-I drug?

   1. Decreased production of Renin

   2. Decreased production of angiotensinogen

   3. Decreased fluid volume in the circulatory system,

   4. All of the above

Answer 1

Ans1:- a) loop diuretics :- to reduce Na + reabsorption

Loop diuretics block Na K+ 2Cl - transporter in the loop of Henle to prevent reabsorption of Na K and Cl-.

ACE inhibitor reduce formation of aldosterone so less water is reabsorbed from tubular fluid.

Thiazide block Na Cl cotransporter in DCT.

K sparing diuretic is spironolactone

Ans2:- c) decrease fluid vol in circulatory system.

Because ACE I inhibit the formation of angiotensin 2 and aldosterone which are responsible for fluid loading in body .