During Endochondral ossification

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Expert Solution

The endochondral bone formation or ossification can be found in the bones associated with joint movements and some parts of the skull base. During the endochondral ossification, the mesenchymal tissue firstly differentiates into cartilagenous tissue. Endochondral bone formation is morphogenetic adaptation which produces continuous bone in certain areas that are prominently stressed.

The steps in endochondral ossification are ,

Mesenchymal cells differentiate into chondrocytes.
The cartilage model of the future bony skeleton and the perichondrium form.
Capillaries penetrate cartilage. Perichondrium transforms into periosteum. Periosteal collar develops. Primary ossification center develops.
Cartilage and chondrocytes continue to grow at ends of the bone.
Secondary ossification centers develop.
Cartilage remains at epiphyseal (growth) plate and at joint surface as articular cartilage.

Sydney Mullin answered 1 year ago

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